| abstract |
FIELD: organic chemistry. SUBSTANCE: products: derivatives of pyranyl-cyanoguanidine of the formula (I) where a, b, c are carbon atoms or one of a, b, c can mean nitrogen and others - carbon atom; R 1 - groups where R 2 - CN; R 3 , R 4 - CH 3 ; R 5 - NO 2 , ethynyl, phenylethynyl; R 6 - H; R 7 - C 1 -C 8 -alkyl, unsubstituted phenyl or phenyl substituted with halogen atom, C 1 -C 8 -alkyl, haloid-C 1 -C 8 -alkyl, lower alkoxy-group or amino-group which is substituted with lower alkyl; R 3 - H or CH 3 or R 7 and R 8 together with bound nitrogen atom form pyrrolidine ring; R 9 - H or CH 3 . Reagent 1: thiourea of the formula where R 7 and R 8 as indicated above. Reagent 2: amine of the formula (III) where R 2 , R 3 , R 4 , R 5 , R 6 and R 9 have values indicated above. Process conditions: in the presence of carbodiimide and acid, in the medium of organic solvent. These compounds show activity with relation to potassium channel activation and can be useful, for example, as cardial-vessel agents, especially as antiischemic agents. Lactic dehydrogenase activity decrease at 10 M - 60%. Synthesized compounds were used in medicine. EFFECT: improved method of synthesis. 1 tbl |