| titleOfInvention |
5-amino-1-hydroxymethylcyclopentane-1,2,3,4-tetraol, 2- amino-4-hydroxymethyl-3a,5,6,6a-tetrahydro-4h-cyclopent- [d]-oxazole-4,5,6-triol, pharmaceutically acceptable salts thereof, and process for preparing thereof |
| abstract |
FIELD: used as biologically aceptable active materials. SUBSTANCE: the product 1: 5-amino-1- hydroxymethylcyclopentane-1,2,3,4-tetrazole of the formula: [α] 25 D = -37 ° . Reagent 1: trehazoline. Reagent 2: 4N aqueous HCl solution. Reaction conditions: at 100 C for 20 to 24 hr. Product 2: 2-amino-4-hydroxymethyl- 3a,5,6,6a-tetrahydro-4H-cyclopent [d]-oxazole-4,5,6-triol of formula: [α] 25 D = +10 ° . Reagent 1: trehazoline. Reagent 2: 0.2 N aqueous HCl solution. Reaction conditions at 100 C for 6 hr. EFFECT: improved properties of the title compounds. 8 cl, 1 dwg, 1 tbl |