http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2045532-C1
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7570d8d27c24a8e26d761bb196fa5eaa http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2be9d9c2a4e8064c74249453fc3afcef |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-234 |
filingDate | 1988-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 1995-10-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5f2ef5115ad4c648863cc7f232159411 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c0b9e4dc368d5302f780c3f28ee0c9ed http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f5332df9a72758990787536f5f0eb6a9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1556103e8cefffbcacb3ba2bc4bd8e7f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_36333426dfbfaa3af326d3133f08d805 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6c540cbf0c65c6ba8afdc1c53d7e2d80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b6c0234d95f26164f858ab61de3e4178 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3f9dae3f9a4e76331bafcfc21d4ab297 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8cb1d432f00f014670330935c0b012ec http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_46dc2b65a7d24233c562983d56e90c6c |
publicationDate | 1995-10-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | RU-2045532-C1 |
titleOfInvention | Process for preparing amicacin as sulfuric acid addition salts |
abstract | FIELD: chemical industry. SUBSTANCE: the product: amicacin sulfate. Reagent 1: an anhydrous complex of 3,6-di-N-benzylo-xycarbonyl kanamycin A with a divalent metal, possibly "in situ". Reagent 2: sulfuric acid. Reaction conditions: reagent 1 is polysilated in anhydrous DMFA, DMSO, pyridine or hexamethylsilazane, optionally by addition of dipicolinic acid or 3-hydroxypyridine. The resulting polysilyl derivative is subjected to reaction of (a) partial hydrolysis using water or alcohol in an amount of 3.3 to 10% with respect to the solvent and there-after acylated with N-hydroxysuccinimide ester of L-(-)-alpha-benzyloxycarbonylamine- alpha-hydroxybutyric acid and (b) hydrogenolysis in water with the addition of methanol at a pH of 1-3, preferably 1.5-2. After purification on ionites and removal of the solvent, sulfuric acid is successively added to adjust a pH to 1-5, preferably 1-2 and alcohol, preferably methanol, in an amount of 20-50% preferably 25-40% of the volume of the aqueous phase. The desired product is of high purity and meets the requirements for substances used as injection solutions. The yield is 49-82% The biological activity is 723 mg/mg per dry matter. EFFECT: more efficient preparation process. |
priorityDate | 1987-12-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 65.