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filingDate 1991-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 1995-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_36ab8c03d1cf5b1dd7f6996c9bfbe1d0
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publicationDate 1995-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber RU-2044729-C1
titleOfInvention Process for preparing 1-benzyl-3-hydroxymethylindazole ethers of pharmaceutically acceptable salts thereof
abstract FIELD: chemical industry. SUBSTANCE: 1-benzyl-3-hydroxymethylindazole of the formula: A-CH 2 -O-CRR′-COOR′′′(1) (1) wherein A is 1-benzylindazol-3-yl; R,R′ are the same or different H or CH 3 ; R″-H is H or a residue of saturated aliphatic C 1 -C 3 -alcohol, or pharmaceutically acceptable salts thereof, if R′′′-H is H. Reagent 1: a compound of the formula: A-CH 2 -OH. Reagent 2: an alkali metal or a derivative thereof. Reaction conditions: the alsoholate thus formed of the formula: A-CH 2 -OMe is treated with a compound of the formula: X-CRR′-COOR′′′ wherein X is halogen, followed optionally by hydrolysis of the compound 1 in which R′′′ is a residue of saturated aliphatic C 1 -C 3 -alcohol to obtain compound 1 in which R′′′-H is H and by conversion thereof into a salt. EFFECT: more efficient preparation process. 1 tbl
priorityDate 1989-02-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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Total number of triples: 40.