| abstract |
FIELD: organic chemistry. SUBSTANCE: product: 1,3-dioxane derivatives of alkenoic acid of the formula (I) where A 1 -C 1 -C 6 -alkylene; R 1 -C 1 -C 6 -alkyl, trifluoromethyl, C 3 -C 6 -cycloalkyl, C 1 -C 4 -alkoxy-C 1 -C 4 -alkyl or a group: R 3 -A 2 at R 3 pyridyl, phenyl, non- or mono- or disubstituted with hydrogen, trifluoromethyl, nitro or cyano-group, and A 2 0 C 1 -C 6 -alkylene, hydroxy-C 1 -C 6 -alkylene, C 2 -C 6 -alkenylene or direct bond with R 3 ; R 2 - hydroxy-group, or physiologically acceptable alcohol moiety; X hydrogen, hydroxide or C 1 -C 4 -alkoxy-group; Y vinylene, n=1 or 2, or their pharmaceutically salt. For substances of the formula (I) the value pA 2 showing antagonism TXA 2 capability is 5.4-7.95 rel. units. Synthetase inhibition is carried out by using microsomatic method, and results are 0.05-0.31 μm. Synthesized compounds were used in medicine. The formula (I) is given in the description of invention. EFFECT: increased effectiveness of synthesized compounds. |