http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2015975-C1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7762dcef122752c38949d6b09994c029 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-513 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-08 |
| filingDate | 1992-02-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1994-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5e31d42541663a43d574e8f9f132c052 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_948b4e240fd5c122dd54a10f08f4332f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2f861a08e1e9e1e183003f01b3878a43 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d6e1da8edad01585f597ff1a7d27657d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c94dcd11c0b5cdb1debf53a26b2456ea |
| publicationDate | 1994-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2015975-C1 |
| titleOfInvention | 4-oxo-1,4-dihydropyrimidine derivatives having antiallergic and immunotropic activity |
| abstract | FIELD: chemico-pharmaceutical industry and medicine. SUBSTANCE: 4-oxo-1,4-dihydropyrimidime DERIVATIVES of the formula: having antiallergic and immunotropic activity. Reagent 1: 2,6-dimethyl-1,5-diphenyl-4-oxo-1,4-dihydropyrimidine or 2.5-dimethyl-5-phenyl-1-(3-pyridinyl)-4-oxo-1,4-dihydropyridine. Reagent 2: 4-methoxybenzaldehyde, 4-hydroxybenzaldehyde. The process is carried out in a mixture of dimethyl sulfoxide and ethanol on boiling; the yield is 53-71%. R 1 -C 6 H 5 R 2 -OCH 3 ; the molecular weight is 394; mp 261-263 C; C 20 H 19 N 2 O, R 1 -C 6 H 5 , R 2 -OH, the molecular weight is 380 mp 317-319 C; C 19 H 17 N 2 O 2 , R 1 -C 6 H 5 , R 2 -3-pyridyl; the molecular weight is 395; mp 238-241 C, C 27 H 18 N 3 O com pounds are nontoxic (LD 50 mg/kg) and have marked antiallergic and immunostimulating activity. EFFECT: improved properties of the title compounds. 3 tbl |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2675694-C1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2643356-C2 |
| priorityDate | 1992-02-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 55.