http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2015113597-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y207-11001 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-472 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4745 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44 |
| filingDate | 2013-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2015113597-A |
| titleOfInvention | AMINOISOCHINOLINE DERIVATIVES AS PROTEINKINASE INHIBITORS |
| abstract | 1. The compound of formula (I): or a tautomer thereof, a prodrug, or a pharmaceutically acceptable salt or solvate, wherein: Y is hydrogen or C-C1-6alkyl, and Z is selected from hydrogen, halogen, C-C1-6alkyl, C-haloalkyl, C- Alkoxy, C-haloalkoxy and -NRR; or alternatively, Y and Z are linked by a double bond (“Z = Y”), and each of them independently represents CR, CR or a nitrogen atom (N), where each of R and R is independently selected from hydrogen, halogen, hydroxyl, C-C1-6alkyl, C-Cycloalkyl, C-Haloalkyl, C-Salkoxy and C-Haloalkoxy; each of X, X, Xi is independently selected from hydrogen, halogen, hydroxyl, C-C1-6alkyl, C-Haloalkyl, C-Salkoxy and C-Haloalkoxy; R is selected from C-C1-6alkyl, C-Cycloalkyl, C-Saryl and 5-10 membered heteroaryl, 5-10 membered heterocyclyl, C-Cycloalkyl- (C-C) alkyl, C-Saryl- (C-C) alkyl, 5 -10-tsp heteroaryl- (C-C) alkyl and 5-10 membered heterocyclyl- (C-C) alkyl, each of which is optionally substituted with one, two or three substituents independently selected from halogen, hydroxyl, C-C1-6 alkyl, C-Haloalkyl , C-Salkoxy, C-Haloalkoxy, -NRR, cyano, nitro, oxo, -C (O) R, -C (O) OR and -C (O) NRR, R is hydrogen or C-C1-6alkyl, or alternatively, R and R, together with the nitrogen (N) and sulfur (S) atoms to which they are attached form a five- or six-membered ring, R represents hydrogen, C-C1-6alkyl, C-Saryl, benzyl, -C (O) R, or - C (O) OR, each of which is not optionally substituted with one, two or three substituents independently selected from halogen, C-C1-6alkyl, halogenated, C-Salkoxy, C-Salkoxy, cyano and -NRR, each of R, R, R and R independently represents hydrogen, halogen, C-Salkyl, C-haloalkyl, C-Salkoxy and C-Haloalkoxy; each of R and R is independently selected from hydrogen, C-C1-6alkyl, benzyl and —C (O) OR, and R is hydrogen or |
| priorityDate | 2012-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 83.