http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2015113521-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2236-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2236-35 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23V2002-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A21D2-266 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K36-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23L33-105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A23L1-30 |
| filingDate | 2013-10-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2015113521-A |
| titleOfInvention | METHOD FOR PRODUCING RICH Coffeoylquinic Acid Extracts from Helianthus Annuus |
| abstract | 1. A method of producing Helianthus annuus extracts, in which: a) Helianthus annuus seeds are extracted with aqueous mixtures of aliphatic alcohols, obtained by extraction with hexane, followed by removal of the solvent at temperatures above 100 ° C; b) the aqueous-alcoholic solution from stage a) is concentrated under vacuum until the alcohol solvent is completely removed and any residual insoluble substances and fatty phases are filtered off; c) the pH of the aqueous solution from step b) is adjusted to pH 5; d) the aqueous solution from step c) is ultrafiltered on an organic membrane ah cutoff 10 kDa, e) solution is subjected to step d) of nanofiltration or chromatography, f) concentrated retentate of step d) under vacuum or by raspyleniya.2. The method of claim 1, wherein in step a), the extraction is carried out with ethanol / water mixtures in the presence of organic or inorganic acids capable of maintaining a pH below 2.3. The method according to claim 2, where in stage a) the extraction is carried out with mixtures of 80% v / v. ethanol / water in the presence of dilute sulfuric acid. 4. The method of claim 1, wherein in step c) the pH of the aqueous solution is adjusted to about 5 using calcium carbonate. The method according to claim 1, wherein, in step d), the solution is chromatographed on an absorption resin using a polystyrene resin and / or ion exchange and absorption resin. The method according to claim 1, wherein in step d) the solution is subjected to nanofiltration using a ceramic membrane with a cut-off of 400 to 600 Da. Extracts of Helianthus annuus obtained by the method according to any one of paragraphs. 1-6.8. The extracts of Helianthus annuus according to claim 7, having a caffeoylquinic acid content in the range of 40 to 80%, preferably 50 to 60%. Extracts of Helianthus annuus according to claim 7 or 8, forming a complex with plant or animal proteins. 10. Compositions containing Helianthus annuus extracts by |
| priorityDate | 2012-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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