| abstract |
1. An improved method of treatment with pirfenidone, comprising reducing the dose of pirfenidone administered to the patient from about half to about one third during the concomitant administration of ciprofloxacin at a dose of 750 mg twice a day (1500 mg / day) .2. A method of treating pirfenidone in a patient in need thereof, comprising administering to the patient a therapeutically effective amount of pirfenidone without concomitant administration of ciprofloxacin in a dose of 750 mg. 3. A method according to claim 1, characterized in that the dose of pirfenidone is reduced from about 2403 mg / day to a dose in the range from about 1400 mg / day to about 1650 mg / day, in some cases 1602 mg / day, during the administration of ciprofloxacin. . The method according to claim 1, characterized in that the dose of pirfenidone is reduced from about 1800 mg / day to a dose in the range from about 1000 mg / day to about 1250 mg / day, in some cases 1200 mg / day, during the administration of ciprofloxacin. . The method of claim 1, wherein the method is intended to prevent a possible decrease in the clearance of pirfenidone or a possible increase in the effect of pirfenidone. The method according to claim 3, characterized in that the total daily dose of pirfenidone is administered to the patient in divided doses three times a day, with food. A method according to claim 1, characterized in that pirfenidone is administered in unit dosage forms, which are capsules or tablets. A method according to claim 7, characterized in that the amount of pirfenidone in a unit dosage form is 200 mg or 267 mg. The method according to claim 3, characterized in that during the concomitant administration of ciprofloxacin 534 mg pirfenidone is administered to the patient three times a day, with food. The method according to p. 3, characterized in that during the concomitant administration of ciprofloxacin, pirfenidone is administered in a total daily dose of 1602 |