http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2015110985-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-472 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4375 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4725 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 |
| filingDate | 2013-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2015110985-A |
| titleOfInvention | SERIN / THREONIN KINASE INHIBITORS FOR THE TREATMENT OF HYPERPROLIFERATIVE DISEASES |
| abstract | 1. The compound according to formula I where: X is CH or N; Z is (i) NH (CH) CHRAr, where n is 0 or 1, or (ii) 1-alkyl-4-aryl-pyrrolidin-3 -ylamine or 4-aryl-pyrrolidin-3-ylamine, where alkyl is C1-6alkyl optionally substituted with a phenyl ring, and aryl is optionally substituted phenyl; R4 represents (a) hydrogen, (b) C-C1-6alkyl optionally substituted with one or more hydroxyl or Salkoxy groups, (c) C-Salkenyl optionally substituted with one or more hydroxyl or Salkoxy groups, (g) C- alkynyl with one or more hydroxyl or Salkoksigrupp, (d) C-cycloalkyl, optionally substituted with one or more groups selected from the group consisting of hydroxyl, alkoxy, halogen and C ^ alkyl; (e) a 4-6 membered heterocycle containing 1 or 2 heteroatoms selected from N or O, where the heterocycle is optionally substituted with one or more groups selected from the group consisting of hydroxyl, Salkoxy, C 1-6alkyl and halogen, or (g) 5 A 6-membered heteroaryl containing 1 or 2 heteroatoms selected from N or O, wherein the heteroaryl is optionally substituted with one or more groups selected from the group consisting of hydroxyl, Salkoxy, C1-6alkyl and halogen; Ar is phenyl, pyridinyl or indolyl, optionally substituted with 1-3 groups independently selected from (a) Ca alkyl, (b) Haloalkyl, (c) Salkoxy, (d) Cycloalkyl, (e) halogen, (e) Haloalkoxy, (g) Salkylthio, (e) cyano, (g) benzyl, (h) phenoxy, where benzyl is indicated and phenoxy optionally substituted with halogen, C1-6alkyl or Salkoxy, (i) 4-methylpiperazin-1-yl or (i) heteroaryl selected from the group consisting of pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl and pyrazolyl, wherein said heteroaryl is optionally substituted |
| priorityDate | 2012-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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