http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2015110163-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4725 |
| filingDate | 2015-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2015110163-A |
| titleOfInvention | PHARMACEUTICAL COMPOSITIONS OF BIS-BENZYLISOCHINOLINE ALKALOID, THEIR APPLICATION AND METHOD FOR PREVENTING OR INHIBITING THE PERMISSION OF FILOVIRUS IN A CELL USING THE SPECIFIED COMPOSITIONS |
| abstract | 1. A pharmaceutical composition for preventing or inhibiting the penetration of filovirus into a human cell, containing a therapeutically effective amount of tetrandrin or a pharmaceutically acceptable derivative thereof, characterized in that at pH 6.8 and a temperature of 37 ° C provides a release of at least 80% tetrandrin within 45 minutes. . The pharmaceutical composition according to claim 1, characterized in that it contains: 35-50 wt.% Tetrandrine or a pharmaceutically acceptable salt or solvate thereof, 38-49.5 wt.% Pharmaceutically acceptable excipient, 4-5 wt.% Binder, 2- 5 wt.% Disintegrant, 0.5-1.5 wt.% Glidant, 0.5-2.7 wt.% Surfactants 0.7-1.0 wt.% Lubricants, the rest .3. The pharmaceutical composition of claim 1, wherein the pharmaceutically acceptable tetrandrine derivative is a pharmaceutically acceptable tetrandrin salt, such as dihydrochloride. A pharmaceutical composition according to claim 1, characterized in that the pharmaceutically acceptable tetrandrin derivative is a pharmaceutically acceptable tetrandrin solvate selected from tetradrin acetone solvate and tetrandrin acetonitrile solvate. The pharmaceutical composition according to claim 2, characterized in that the pharmaceutically acceptable excipient is selected from microcrystalline cellulose or its derivatives, starch, sodium starch glycolate, pregelatinized starch, lactose, glucose, dextrin, sorbitol, xylitol, mannitol, siliconized cellulose, aluminum sulfate chloride, calcium phosphate, pharmaceutically acceptable equivalents or combinations thereof. 6. The pharmaceutical composition according to claim 2, |
| priorityDate | 2015-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 105.