http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2015107018-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4725 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 |
| filingDate | 2013-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2015107018-A |
| titleOfInvention | Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and diseases of the gastrointestinal tract |
| abstract | 1. A compound having the structure of formula (I): or a stereoisomer, prodrug or pharmaceutically acceptable salt thereof, wherein: (a) NHE (Na + / H + exchanger) is an NHE-inhibiting low molecular weight moiety having the following structure of formula (A) : where: each R, R, R, R and R are independently selected from H, halogen, -NR (CO) R, - (CO) NRR, -SO-NRR, -NRSOR, -NRR, -OR, -SR, -O (CO) NRR, —NR (CO) OR and —NRSONR, where R and R are independently selected from H, C1-6alkyl, —Calkyl-OH, or a bond connecting an NHE-inhibiting small molecule to L, provided that at least one of them is a bond joining NHE- an inhibitory small molecule to L; R is selected from H, C-C1-6alkyl or a bond connecting an NHE-inhibiting small molecule to L; R is absent or selected from H and C-C1-6alkyl; and Ar1 and Ar2 independently represent an aromatic ring or heteroaromatic ring; (b) Core is a core moiety having the following structure of formula (C): where: X is selected from C (X), N and group N (C1-6alkyl); X is selected from hydrogen optionally substituted alkyl, -NXX, -NO, -NX-C (= O) -NX-X, -C (= O) NX-X, -NX-C (= O) -X, -NX-SO- X, —C (= O) —X, and —OX, each X and X is independently selected from hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, possibly substituted heterocyclyl, possibly substituted heterocyclylalkyl, optionally substituted substituted aryl, possibly substituted aralkyl, possibly substituted heteroaryl and possibly substituted heteroarylalkyl; Y is C1-6 alkylene; Z is selected from -NZ-C (= O) -NZ-, -C (= O) NZ-, -NZ-C (= O) - and heteroaryl, where X is CX; Z is selected from -NZ-C (= O) -NZ-, -NZ-C (= O) - and heteroaryl, where X is N or N (C1-6 alkyl); each Chi Z is independently selected from hydrogen and C1-6alkyl; and (c) L is a bond or linker connecting the core moiety to NHE-inhibiting low molecular weight moieties. 2. The compound of claim 1, wherein the NHE is inhibitory |
| priorityDate | 2012-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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