| abstract |
1. The compound of Formula (I) having the structure: in which: A is a carboxylic acid isoster; X is CR or N; R is H, substituted or unsubstituted alikyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl; each R and R are independently selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl; or R and R, together with the carbon to which they are attached, form a cycloalkyl or heterocycloalkyl ring; or a pharmaceutically acceptable salt, solvate or prodrug thereof. 2. A compound of Formula (II) having the structure: wherein: A is a carboxylic acid isoster; X is CR or N; R is H, substituted or unsubstituted alikyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; each R and R are independently selected from H, substituted or unsubstituted alkyl, or substituted or unsubstituted heteroalkyl; or R and R, together with the carbon to which they are attached, form a cycloalkyl or heterocycloalkyl ring; or a pharmaceutically acceptable salt, solvate or prodrug thereof. 3. A compound according to claim 1 or 2, wherein A is a carboxylic acid isoster, selected from: 4. A compound according to claim 1 or 2, wherein A is a carboxylic acid isoster, selected from —SOH, —SONHR, —P (O) (OR), —P (O) (R) (OR), —CON (R ), -CONHNHSOR, -CONHSOR, -B (OR), -C (R) B (OR) and -CON (R) C (R) B (OR); where each R independently is H, OH, substituted or unsubstituted alkyl, or substituted or unsubstituted aryl; and R is H |