http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2015104495-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-68 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-08 |
| filingDate | 2013-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2015104495-A |
| titleOfInvention | LIQUID COMPOSITION OF LONG-TERM INSULIN CONJUGATE |
| abstract | 1. A liquid composition of a long-acting insulin conjugate containing a pharmaceutically effective amount of a long-acting insulin conjugate, where the physiologically active peptide insulin is bound to the immunoglobulin Fc region, and an albumin-free stabilizer that contains a buffer, sugar alcohol, a nonionic surfactant substance and isotonic agent. 2. The long-acting liquid insulin conjugate composition of claim 1, wherein the buffer is a citrate buffer, acetate buffer or phosphate buffer. The long-acting liquid insulin conjugate composition of claim 1, wherein the insulin has the same amino acid sequence as native insulin. The liquid composition of the long acting insulin conjugate of claim 1, wherein the insulin is a derivative of insulin derived from native insulin by amino acid substitution, deletion or insertion, or a peptide analogue exhibiting activity similar to native insulin. The liquid composition of the long acting insulin conjugate of claim 1, wherein the immunoglobulin Fc region is an Fc region derived from IgG, IgA, IgD, IgE or IgM. The liquid composition of the long-acting insulin conjugate according to claim 5, wherein the immunoglobulin Fc region is a hybrid of domains from various sources derived from immunoglobulins selected from the group consisting of IgG, IgA, IgD, IgE and IgM. The liquid composition of the long acting insulin conjugate according to claim 5, wherein the immunoglobulin Fc region is a dimer or multimer consisting of single chain immunoglobulins consisting of domains from the same source. Liquid |
| priorityDate | 2012-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 140.