http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2015103065-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C55-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 |
| filingDate | 2013-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2015103065-A |
| titleOfInvention | CRYSTALLINE FORM I DYMALATE OF A TYROZINKINASE INHIBITOR AND METHOD FOR PRODUCING IT |
| abstract | 1. Crystals of Form I (R, E) -N- (4- (3-chloro-4- (pyridin-2-yl-methoxy) phenylamino) -3-cyano-7-ethoxyquinolin-6-yl) -3 dimaleate - (1-methylpyrrolidin-2-yl) acrylamide, characterized in that when using Cu-Kα radiation to obtain X-ray diffraction patterns represented by 2θ angles and interplanar spacing in the crystals, the crystals are characterized by an X-ray diffraction pattern, as shown in FIG. 1, on which the characteristic peaks are: 6.28 (14.06), 6.74 (13.10), 10.60 (8.34), 11.58 (7.64), 13.50 (6, 55), 14.90 (5.94), 15.80 (5.60), 18.26 (4.85), 20.66 (4.30), 21.14 (4.20), 22, 96 (3.87), 24.34 (3.65), 25.54 (3.49) and 26.12 (3.41) .2. The method of obtaining crystals of form I of the dimaleate (R, E) -N- (4- (3-chloro-4- (pyridin-2-yl-methoxy) phenylamino) -3-cyano-7-ethoxyquinolin-6-yl) -3 - (1-methylpyrrolidin-2-yl) acrylamide according to claim 1, comprising the following stages: 1) a mixture of any crystalline or amorphous form (R, E) -N- (4- (3-chloro-4- (pyridin-2) -yl-methoxy) phenylamino) -3-cyano-7-ethoxyquinolin-6-yl) -3- (1-methylpyrrolidin-2-yl) acrylamide and maleic acid or any crystalline form or amorphous form of dimaleate (R, E) - N- (4- (3-chloro-4- (pyridin-2-yl-methoxy) phenylamino) -3-cyano-7-ethoxyquinolin-6-yl) -3- (1-methylpyrrolidin-2-yl) acrylamide tv The atomic state is heated to dissolve in a sufficient amount of an organic solvent, then cooled to crystallize, wherein said organic solvent is one or more solvents selected from alcohol with no more than 3 carbon atoms, acetone, ethyl acetate, tetrahydrofuran, preferably ethanol, isopropyl alcohol tetrahydrofuran; 2) the crystals are filtered, washed and dried. 3. The method according to claim 2, characterized in that the organic solvent in step 1) is isopropyl alcohol. The method according to claim 2, characterized in that the organic solvent in step 1) is a mixture of ethanol and tetrahydrofuran. |
| priorityDate | 2012-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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