http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2015101532-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4985 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-55 |
| filingDate | 2013-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2015101532-A |
| titleOfInvention | SUBSTITUTED Bicyclic Alcohol-Pyrazole Analogs as Allosteric Modulators of MGLUR5 Receptors |
| abstract | 1. A compound having a structure represented by the formula: wherein R 1 represents aryl or heteroaryl and is substituted with 0, 1, 2 or 3 groups, each of which is independently selected from cyano, halogen, hydroxyl, C1-C4 alkyl, C1-C4 alkyloxy, C1-C4 monohaloalkyl and C1-C4 polyhaloalkyl; where each of R and R is independently selected from hydrogen and C1-C4 alkyl; where R is selected from hydrogen, halogen, cyano, C1-C4 alkyl, C1-C4 monohaloalkyl and C1-C4 polyhaloalkyl; where each of R and R is selected from hydrogen, halogen, -C4 alkyl, C1-C4 monohaloalkyl, C1-C4 polyhaloalkyl, C1-C4 alkyloxy, hydroxy (C1-C4a alkyl) and (C1-C4alkyloxy) - (C1-C4alkyl) -; or R and R are covalently bonded and, together with the intermediate carbon atom, form an optionally substituted 3-7 membered spirocycloalkyl; where each of R and R is selected from hydrogen, halogen, C1-C4 alkyl, C1-C4 monohaloalkyl, C1-C4 polyhaloalkyl, C1-C4 alkyloxy, hydroxy ( C1-C4alkyl) and (C1-C4alkyloxy) - (C1-C4alkyl) -; or R5a and R5b are covalently linked and, together with the intermediate carbon atom, form an optionally substituted 3-7 membered spirocycloalkyl; where R is selected from hydrogen, C1-C8 alkyl, C1-C8 monohaloalkyl, C1-C8 polyhaloalkyl, hydroxy (C1-C8 alkyl), (C1 -C6 alkyl) -O- (C1-C6 alkyl) -, (C1-C6 monohaloalkyl) -O- (C1-C6 alkyl) -, (C1-C6 polyhaloalkyl) -O- (C1-C6 alkyl) -, (C1-C6 alkyl) -NH - (C1-C6 alkyl) -, (C1-C6 alkyl) (C1-C6 alkyl) N- (C1-C6 alkyl) -, Cy, Cy- (C2-C6 alkyl) - and Cy-C (R) (R) - ; where Su, if present, is selected from C3-C8 cycloalkyl, C2-C7 heterocycloalkyl, phenyl, monocyclic heteroaryl and bicyclic heteroaryl; and where Su, if present, is substituted with 0, 1, 2 or 3 groups, each of which is independently selected from halogen, cyano, —NH, mono (C1-C6 alkyl) amino, di (C1-C6 alkyl) amino, C1-C4 alkyl , C1-C4alkyloxy, (C1-C4alkyloxy) - (C1-4alkyl) -, (C1-C4alkyloxy) - (C1-C4alkyloxy) -, C1-C4monohaloalkyl, C1-C4 polyhaloalkyl, (C1-C4 polyhaloalkyl) - (C1- C4 alkyloxy) -, C3-C6 cycloalkyl, |
| priorityDate | 2012-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 51.