http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2015100280-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C47-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D309-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C35-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C65-03 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C69-84 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 |
| filingDate | 2013-06-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2015100280-A |
| titleOfInvention | MULTI-COMPONENT CRYSTALS CONTAINING DAZATINIB AND DEFINED CO-CRYSTAL FORMERS |
| abstract | 1. A multi-component crystalline system (co-crystal) containing a compound of formula 1 and a second compound selected from methyl 4-hydroxybenzoate, or nicotinamide, or ethyl gallate, or methyl gallate, or propyl gallate, or ethyl maltol, or vanillin, or menthol, or (1R, 2S 5R) - (-) - menthol. 2. A multicomponent crystalline system according to claim 1, characterized in that the molar ratio of the compound of formula 1 to the second compound is in the range from 7: 1 to 1: 1.3. A multicomponent crystalline system according to claim 1 or 2, characterized in that the second compound is methyl 4-hydroxybenzoate and has an X-ray powder diffraction pattern with at least one characteristic peak (expressed in units of 20 ± 0.2 ° 2θ (CuKα radiation)) at 6.0, 6.9, 12.0,12.4, 13.2, 24.3 °; especially at 6.0, 6.9, 12.0, 12.4, 13.2, 13.8, 15.3, 16.8, 21.0, 24.3, 24.8, 26.7 °. 4. A multicomponent crystalline system according to claim 1 or 2, characterized in that the second compound is nicotinamide and has an X-ray powder diffraction pattern with at least one characteristic peak (expressed in units of 20 ± 0.2 ° 2θ (CuKα radiation)) at 5.4, 5.9 , 6.9, 12.4, 13.2, 24.4 °; especially at 5.4, 5.9, 6.9, 11.8, 12.4, 13.2, 13.8, 15.1, 16.8, 17.7, 21.2, 24.4, 24.9 °. 5. A multicomponent crystalline system according to claim 1 or 2, characterized in that the second compound is ethyl gallate and has an X-ray powder diffraction pattern with at least one characteristic peak (expressed in units of 20 ± 0.2 ° 2θ (CuKα radiation)) at 5.9, 6.9 , 12.4, 13.2, 16.7, 21.1, 24.4 °; especially at 5.9, 6.9, 12.4, 13.2, 13.8, 16.7, 17.2, 21.1, 21.8, 24.4, 24.9, 27.8 °. 6. A multicomponent crystalline system according to claim 1 or 2, characterized in that the second compound is ethyl maltol and has an X-ray powder diffraction pattern with at least one characteristic peak (expressed in units of 20 ± 0.2 ° 2θ (CuKα radiation)) at 5.9, 6.9 , 11.8, 12.4, 13.2, 16.8 °; especially |
| priorityDate | 2012-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 51.