http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2014150435-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4184 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4178 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-04 |
| filingDate | 2013-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2014150435-A |
| titleOfInvention | GETTING AN ANTI-VIRUS COMPOUND |
| abstract | 1. A method of obtaining a compound of formula I:, or a pharmaceutically acceptable salt thereof, comprising (A) a reaction of combining a compound of formula (i) with a compound of formula (ii) in the presence of a metal catalyst and a base to obtain a compound of formula (iii) or its salt :( B) deprotecting a compound of formula (iii) to give a compound of formula (iv): or a salt thereof; (C) contacting a compound of formula (iv) with (S) -2- (methoxycarbonylamino) -3-methylbutanoic acid: s obtaining the compounds of formula I; moreover, each of PG independently represents a protective group of an amino group; Y and Z are independently selected from Br and —B (OR) (OR ′), wherein when Y is —B (OR) (OR ′), then Z is Br and Y is Br, then Z is —B ( OR) (OR ′); and R and R ′ are independently selected from the group consisting of hydrogen and straight or branched C-alkyl, or R and R ′ together are straight or branched C-alkylene, C-cycloalkylene or C-arylene, wherein any alkyl, alkylene, cycloalkylene or arylene is optionally substituted with one or more substituents selected from the group consisting of C-alkyl, —C (O) N (C-alkyl), and —C (O) O (C-alkyl). 2. The method of claim 1, wherein Y is —B (OR) (OR ′) and Z is Br. 3. The method of claim 2, further comprising the step of forming the compound of formula (i) under in situ conditions, comprising sequentially bringing the compound of formula (a) into contact with a palladium source, and then with a boronating agent containing a group: in the presence of a second base, provided that the compound of formula (i) is formed in situ, and X is a halide selected from O, Br and I.4. The method according to p. 3, characterized in that the stage of formation of the compounds of formula (i) in situ and stage (A) are carried out in a single reactor |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2705809-C2 |
| priorityDate | 2012-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 45.