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filingDate 2013-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2016-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber RU-2014146772-A
titleOfInvention NEW ROTAVIRAL VACCINE COMPOSITIONS AND METHOD FOR PRODUCING THE ABOVE COMPOSITIONS
abstract 1. A liquid vaccine formulation containing i. rotavirus antigen; ii. combined buffer system iii. combination of sugars; iv. human recombinant serum albumin; v. partially hydrolyzed protein, lactalbumin hydrolyzate. 2. The vaccine composition according to claim 1, wherein the combined buffer system is a citrate-bicarbonate buffer system. The vaccine composition according to claim 2, where the concentration of citrate is in the range from 0.01 to 0.05 M. The vaccine composition according to claim 2, where the concentration of bicarbonate is in the concentration range from 0.01 to 2 M.5. The composition of the vaccine according to claim 3, where the concentration of citrate is 0.03 M.6. The vaccine composition according to claim 4, where the concentration of bicarbonate is 0.3 M.7. The vaccine composition according to claim 1, wherein the combined buffer system is a carbonate-bicarbonate buffer system. The vaccine composition according to claim 7, where the concentration of carbonate-bicarbonate buffer is in the range from 0.01 to 0.5 M. The vaccine composition of claim 8, wherein the carbonate-bicarbonate buffer is present at a concentration of 0.1 M.10. The vaccine composition of claim 8, wherein the carbonate-bicarbonate buffer is present at a concentration of 0.2 M. 11. The vaccine composition of claim 1, wherein the combined buffer system is a buffer system with magnesium hydroxycarbonate. The vaccine composition according to claim 11, wherein the combined buffer system with magnesium hydroxycarbonate is in a concentration range from 0.01 to 0.5 M. The vaccine composition of claim 12, wherein the magnesium hydroxycarbonate is present at a concentration of 0.1 M. The vaccine composition according to claim 1, wherein the combined buffer system is a mixed buffer system containing ammonium acetate, ammonium bicarbonate and diammonium orthophosphate. The vaccine composition of claim 14, wherein the mixed buffer is in a concentration range from 0.01 M to 2 M.16.
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