http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2014144647-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N1-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y101-01028 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y101-01027 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0006 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21 |
| filingDate | 2013-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2014144647-A |
| titleOfInvention | NEW STRAIN PRODUCING D-LACTIC ACID AND ITS APPLICATION |
| abstract | 1. A strain producing D-lactic acid, modified to attenuate or inactivate the activity of L-lactate dehydrogenase (L-LDH) and to enhance the activity of D-lactate dehydrogenase (D-LDH). 2. The strain of claim 1, wherein the L-LDH encoding polynucleotide is selected from the group consisting of Idh (SEQ ID NO: 25) and Idh1 (SEQ ID NO: 26) Lactobacillus paracasei, Idh1 (SEQ ID NO: 27) and Idh2 ( SEQ ID NO: 28) Lactobacillus paracasei, Idh (LGG_02523) (SEQ ID NO: 29) and Idh (LGG_00606) (SEQ ID NO: 30) Lactobacillus rhamnosus. 3. The strain of n. 1, where the D-LDH coding polynucleotide is derived from Lactobacillus plantarum or Lactobacillus delbrueckii. 4. The strain of claim 3, wherein the D-LDH encoding polynucleotide is an LDHA encoding polynucleotide (lactate dehydrogenase-A) (SEQ ID NO: 31) Lactobacillus delbrueckii or LDHD encoding polynucleotide (lactate dehydrogenase-D) (SEQ ID NO: 32) Lactobacillus plantarum. 5. The strain of claim 1, wherein the one or more heterogeneous D-LDH coding polynucleotides replace the L-LDH coding polynucleotide on the chromosome and are overexpressed. The strain of claim 1, wherein the strain is a strain of Lactobacillus sp. 7. The strain of claim 1, wherein the polynucleotide encoding LDH1 (SEQ ID NO: 27) and the polynucleotide encoding LDH2 (SEQ ID NO: 28) Lactobacillus casei are replaced by a polynucleotide encoding LDHA (SEQ ID NO: 31) Lactobacillus delbrueckii, and polynucleotide encoding LDHD (SEQ ID NO: 32) of Lactobacillus plantarum, respectively. 8. The strain of claim 1, wherein the polynucleotide encoding LDH (SEQ ID NO: 25) and the polynucleotide encoding LDH1 (SEQ ID NO: 26) Lactobacillus paracasei are replaced by a polynucleotide encoding LDHA (SEQ ID NO: 31) Lactobacillus delbrueckii, and polynucleotide encoding LDHD (SEQ ID NO: 32) of Lactobacillus plantarum, respectively. 9. The strain of claim 1, wherein the polynucleotide encoding LDH (LGG_02523) (SEQ ID NO: 29) and the polynucleotide encoding LDH (LGG_00606) (SEQ ID NO: 30) Lactobacillus rhamnosus are replaced by a polynucleotide encoding LDHA (SEQ ID NO: 31) Lactobacillus delbrueckii, and a polynucleotide encoding LDHD (SEQ ID NO: 32) Lactobacillus plantarum, respectively. 10. The strain of claim 8, which is Lactobacillus paracasei CC02-0095, deposited with access number KCCM11273P.11. A method of obtaining a modified strain producing D-lactic acid, including: a) weakening or inactivation of the activity of L-lactate dehydrogenase (L-LDH) in a strain producing L-lactic acid, to obtain a modified strain, producing |
| priorityDate | 2012-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 74.