http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2014139974-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-75 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-75 |
| filingDate | 2013-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2014139974-A |
| titleOfInvention | IMPROVED PROCESS OF OBTAINING FIBRINOGEN AND FIBRINOGEN OBTAINED IN THIS WAY |
| abstract | 1. A method of purifying a source containing fibrinogen by precipitating fibrinogen from a solution containing fibrinogen in the presence of one or more chelating agents (a) and removing the supernatant from the fibrinogen paste, characterized in that the fibrinogen is extracted from the paste forming a liquid fraction containing fibrinogen and an undissolved residue that separates from the liquid in the absence of the addition of one or more protease inhibitors (a). 2. The method of claim 1, wherein the one or more protease inhibitors (a) are selected from C1 protease inhibitors, trypsin inhibitors, thrombin inhibitors, antithrombin III (AT-III), cofactor heparin II, aprotinin, pepstatin, leipeptin and epsilon aminocaproic acid. 3. The method according to one of paragraphs. 1 or 2, where one or more of the chelating agents (a) is a Ca2 + chelating agent selected from 1,2-bis (o-amino) ethane-Ν, Ν, Ν ', Ν'-tetraacetic acid (BAPTA) diethylenetriaminepentaacetic acid (DTPA), ethylenediaminetetraacetic acid (EDTA), ethylene glycol tetraacetic acid (EGTA) and nitrilotriacetic acid (NTA). 4. The method according to one of paragraphs. 1 or 2, where the concentration of the chelating agent is in the range of 3 mM to 100 mM. 5. The method according to one of paragraphs. 1 or 2, where the concentration of the chelating agent is in the range of 5 mM to 50 mM. 6. The method according to one of paragraphs. 1 or 2, where the concentration of the chelating agent is in the range of 5 mM to 20 mM. 7. The method according to one of paragraphs. 1 or 2, where fibrinogen is precipitated in the temperature range from 4.1 ° C to 40 ° C, in particular in the range from 5 ° C to 37 ° C, using a precipitating agent, which, in particular, is selected from the group consisting of amino acids, polyethylene glycol or salts in high concentrations or combinations thereof, where the salt contains one |
| priorityDate | 2012-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 56.