http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2014138619-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1652 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2054 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C309-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C309-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-71 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C309-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C309-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C229-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C309-39 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C309-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C327-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C309-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C219-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C309-59 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C219-22 |
| filingDate | 2013-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2014138619-A |
| titleOfInvention | NEW SULFONATE-BASED TRIMEBUTINE SALTS |
| abstract | 1. The compound of formula I (AX), its diastereoisomer, enantiomer or a mixture thereof: where: R represents hydrogen or methyl; and R 1 represents phenyl unsubstituted or substituted by one to three groups C (= S) NRR, —CN, —COOH, C — C 1-6 alkyl, C 1 -C 2 alkoxy, halogen, C (= 0) NR 2 R or C 1 -C haloalkyl, where each of R and R is independently H, C1-6alkyl, C1-6alkenyl or C1-6alkynyl; or where R 1 is C-C 1-6 alkyl unsubstituted or substituted by one to three groups-OH, C (═S) NRR, —CN, —COOH, C-C 1 alkoxy, halogen, C (═O) NRR or C 1 -C haloalkyl. 2. A compound according to claim 1, wherein R4 is phenyl unsubstituted or substituted by one to three groups C (= S) NRR, -CN, -COOH, C-C 1-6 alkyl, C-C 1 alkoxy, halogen, C (= 0) NRR or C 1 -C haloalkyl wherein each of R and R is independently H, C1-6alkyl, C1-6alkenyl or C1-6alkynyl. 3. A compound according to claim 1, wherein X is phenyl sulfonate, where phenyl is unsubstituted or substituted with —C (═S) NH, —COOH, Cl, —CN or —CH. 4. A compound according to claim 1, wherein X is ethyl sulfonate, unsubstituted or substituted with —OH. The compound of claim 1, wherein X is: 6. A compound according to claim 1, wherein X is 2-thiocarbamoylbenzenesulfonate, 3-thiocarbamoylbenzenesulfonate, 4-toluenesulfonate or 4-thiocarbamoylbenzenesulfonate. A compound according to claim 1, wherein X is 3-thiocarbamoylbenzenesulfonate. A compound according to claim 1, wherein X is 4-toluenesulfonate. A compound according to claim 1, wherein X is isethionate, methanesulfonate or ethanesulfonate. 10. The compound according to any one of paragraphs. 1-9, where R is hydrogen. 11. The compound according to any one of paragraphs. 1-9, where R is methyl. 12. A compound according to claim 1, which is a crystalline polymorph of the salt of trimebutin 3-thiocarbamoylbenzenesulfonate. A compound according to claim 12, wherein the polymorph has a melting point of about 180 ° C. The compound of claim 12 or 13, wherein the polymorph has a powder x-ray diffraction pattern, |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2752086-C1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2777365-C1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022225427-A1 |
| priorityDate | 2012-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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