| abstract |
1. The compound of Formula I or a pharmaceutically acceptable salt, solvate, tautomer or N-oxide thereof: wherein: Y and Y are independently a bond or —N (R) -, wherein at least one of Y and Y is —N ( R) -; L and L independently represent a bond or optionally substituted alkylene; X represents = N - or = C (R) -; X represents = N - or = C (R) -; R and R are independently selected from the group consisting of hydrogen, halogen, —CN, —C (O) —N (R) —R, —C (O) —OR, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclo alkyl, optionally substituted alkoxy, haloalkyl, haloalkoxy, optionally substituted phenyl and optionally substituted 5- or 6-membered heteroaryl; R, R and R are independently selected from the group consisting of hydrogen, halogen, —CN, —C (O) —N (R ) -R, -C (O) -OR, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted alkoxy, haloalkyl, haloalkoxy, optionally substituted phenyl and optionally substituted 5- or 6-membered heteroaryl; R represents both hydrogen, optionally substituted alkyl, optionally substituted alkenyl or optionally substituted alkynyl; R and R are independently hydrogen, optionally substituted alkyl, haloalkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted phenyl, or R and R together with the nitrogen atom to which they are attached form an optionally substituted heterocycloamino; R is selected from the group consisting of hydrogen, optionally substituted alkyl, haloalkyl, optionally substituted schennogo cycloalkyl, optionally substituted hetero |