http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2014133744-A
Outgoing Links
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|---|---|
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| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-27 |
| filingDate | 2013-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2014133744-A |
| titleOfInvention | Compounds and methods of treatment of candidiasis and infections of ASPERGILLUS |
| abstract | 1. A method of killing or inhibiting the growth of Candida or Aspergillus species or preventing or treating a mammal with oral or disseminated candidiasis or Aspergillus infection, comprising contacting the Candida or Aspergillus species with or administering to a mammal in need thereof an effective amount of a compound of formula I where each X is independently O, S or S (= O); each R is independently -CH, - (CH) -NH, - (CH) -NH-C (= NH) NH or - (CH) -NH-C (= O) -R, where each n is independently 1-4 and each R is independently H, CC-alkyl or - (CH) -NH, where each p is independently 1 or and 2; each R denotes independently H, halogen, CF or C (CH); each V denotes H and each V denotes independently -NC (= O) -R, where each R denotes independently - (CH) -NH or - (CH) -NH-C (= NH) NH, where each n is independently 1-4; or each V denotes H and each V denotes independently -S-R, where each R denotes independently - (CH) -NH or - (CH) -NH-C (= NH) NH, where each n is independently 1-4; each R is H, -S- (CH) -NH, -S- (CH) -NH-C (= NH) NH, -O- (CH) -NH or -O- (CH) -NH-C (= NH ) NH, where each m is independently 1-4; or a pharmaceutically acceptable salt thereof; or compounds of formula II where R is H; R is NH; each R is independently - (CH) -R, where R is selected from hydrogen, CC-alkyl, C-C-branched alkyl, CC-cycloalkyl, phenyl optionally substituted with one or more CC-alkyl groups, CC alkoxy groups or halogen groups, and heteroaryl optionally substituted with one or more CC alkyl groups, CC alkoxy groups or halogen groups; each R independently is hydroxyethoxymethyl, methoxyethoxymethyl, polyoxyethylene or - (CH) -V, where q has a value of 1 to 5 and each V is independently selected from amino, hydroxyl, CC-alkylamino, CC-dialkylamino, CC-alkylurea, -NH (CH) NH, -N (CHCHNH), amidine, guanidine, semicarbazone, imidazole, piperidine, piperazine, 4-alkylpiperazine, phenyl optionally substituted with amines |
| priorityDate | 2012-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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