http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2014133467-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1271 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-127 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1278 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127 |
| filingDate | 2013-02-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-04-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2014133467-A |
| titleOfInvention | THERMOSENSITIVE COMPOSITIONS IN THE TYPE OF NANOPARTICLES AND METHOD FOR PRODUCING THEM |
| abstract | 1. A liposome preparation containing a suspension of liposomes containing a gel lipid bilayer and an active agent enclosed within liposomes, wherein said lipid bilayer contains: (i) one or more phospholipids selected from the group consisting of phosphatidylcholines, phosphatidylglycerols, phosphatidylinositols and phosphatidylinositols; ii) one or more phospholipids derivatized with a hydrophilic polymer; and (iii) one or more lysolipids selected from the group consisting of monoacylphosphatidylglycerols, monoacylphosphatidylglycerols, monoacylphosphatidylinositols, monoacylphosphatidyl ethanolamines, wherein the active agent is selected from the group consisting of doxacorubinodinocin dicarubin dicarubicin dicarubicin dicarubicin dicarubicin dicarubicin dicarubin azin , mitomycin, mitoxantrone, vinblastine, vinorelbine and vincristine, and wherein the components of the lipid bilayer are represented in a molar ratio of about 80-90: 2-8: 2-18; and wherein the liposomes in suspension have a size of from about 50 to about 150 nm. 2. The liposome preparation according to claim 1, characterized in that the active agent is doxorubicin, the relative concentration of impurity A after 6 months of storage at a temperature of less than or equal to 8 ° C is less than 0.5%, and impurity A forms a peak with relative a retention time of about 1.4 when analyzed by high performance liquid chromatography (HPLC) on a C18 column with a reversed phase when eluting with a gradient of acetic acid / methanol. 3. A liposome preparation according to claim 2, characterized in that the relative concentration of impurity A after 6 months of storage at a temperature of less than or equal to 8 ° C is less than 0.2%. 4. The liposome preparation according to claim 2, characterized |
| priorityDate | 2012-02-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 65.