http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2014128386-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-501 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-501 |
| filingDate | 2013-02-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2014128386-A |
| titleOfInvention | PI3K Cough Inhibitors |
| abstract | 1. The compound of formula (I) where X is —CH— and Υ is 4-pyridazinyl; or X is -Ν-, and Υ is 4-morpholinyl; or a pharmaceutically acceptable salt thereof for use in the treatment of cough. 2. A compound representing 2,4-difluoro-N- {2- (methyloxy) -5- [4- (4-pyridazinyl) -6-quinolinyl] -3-pyridinyl} benzenesulfonamide: or a pharmaceutically acceptable salt thereof for use in the treatment of cough. 3. The compound of claim 2, which is 2,4-difluoro-N- {2- (methyloxy) -5- [4- (4-pyridazinyl) -6-quinolinyl] -3-pyridinyl} benzene sulfonamide as the free base. four. The compound according to any one of paragraphs. 1-3, where the cough is an idiopathic chronic cough, a cough variant of asthma, a cough associated with a chest tumor or lung cancer, a viral or post-viral cough, cough upper respiratory tract syndrome (UACS), or post-nasal congestion syndrome or cough associated with gastroesophageal reflux disease (both with acid reflux and non-acid content reflux), chronic bronchitis, chronic obstructive pulmonary disease (COPD), interstitial lung disease, stasis oh heart failure, sarcoidosis or infektsiey.5. The use of a compound representing 2,4-difluoro-N- {2- (methyloxy) -5- [4- (4-pyridazinyl) -6-quinolinyl] -3-pyridinyl} benzene sulfonamide: or a pharmaceutically acceptable salt thereof in the manufacture medicines for use in the treatment of cough. 6. A method for treating cough, comprising administering to a patient in need thereof a safe and effective amount of a compound 2,4-difluoro-N- {2- (methyloxy) -5- [4- (4-pyridazinyl) -6-quinolinyl] -3- pyridinyl} -benzenesulfonamide: or a pharmaceutically acceptable salt thereof. |
| priorityDate | 2012-02-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 17.