http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2014124639-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-47 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 |
| filingDate | 2012-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-01-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2014124639-A |
| titleOfInvention | 2- (phenyl or pyrid-3-yl) aminopyrimidine derivatives as modulators of rich leucine repeat kinase 2 (LRRK2) for the treatment of parkinson's disease |
| abstract | 1. The compound of formula I: or its pharmaceutically acceptable salts, in which: m is from 0 to 3; X is: -NRa-; -ABOUT-; or —S (O) r—, wherein r is 0 to 2, and Ra is hydrogen or C-alkyl; Υ is C or Ν; R1 is: C-alkyl; C alkenyl; C-alkynyl; halogen-C-alkyl; C-alkoxy-C-alkyl; hydroxy-C-alkyl; amino-C-alkyl; C-alkylsulfonyl-C-alkyl; C-cycloalkyl optionally substituted with C-alkyl; C-cycloalkyl-C-alkyl, in which the C-cycloalyl group is optionally substituted with C-alkyl; tetrahydrofuranyl; tetrahydrofuranyl-C-alkyl; oxetanyl; or oxetane-C-alkyl; or R1 and Ra together with the atoms to which they are attached can form a ring comprising from three to six members, which optionally contains an additional heteroatom selected from O, N and S, and which is substituted by an oxo group, halogen or C-alkyl; R2 is: halogen; C-alkoxy; cyano group; C-alkynyl; C alkenyl; halogen-C-alkyl; halogen-C-alkoxy; C-cycloalkyl in which the C-cycloalyl group is optionally substituted with C-alkyl; C-cycloalkyl-C-alkyl, in which the C-cycloalyl group is optionally substituted with C-alkyl; tetrahydrofuranyl; tetrahydrofuranyl-C-alkyl; acetyl; oxetanyl; or oxetane-C-alkyl; R3 and R4 each independently represents: halogen; C-alkyl; C-alkoxy; A C-cycloalkyloxy group; halogen-C-alkyl; or a halo-C-alkoxy group; and R5 is a 5 membered heteroaryl optionally substituted with one or more R6; and R6 is: C-alkyl; C-cycloalkyl; C-cycloalkyl-C-alkyl; halogen; halogen-C-alkyl; C-alkoxy; heterocyclyl; oxo group; or —C (O) —NRbRc, where Rb and Rc are each independently hydrogen or —C-alkyl. 2. Connected |
| priorityDate | 2011-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 120.