http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2014123784-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-16 |
| filingDate | 2012-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2014123784-A |
| titleOfInvention | NEW PYRROLIDINE DERIVATIVES AS CATATEPSIN INHIBITORS |
| abstract | 1. A compound of formula (I) in which A is carbonyl or is absent; R represents an alkoxy group, nitrophenyl, 1H-pyrazolyl substituted with alkyl and cycloalkyl, alkylcycloalkyl, haloalkylcycloalkyl, phenylcycloalkyl, pyridinyl cycloalkenyl-r-phenyl, or R; alkyl and cycloalkylalkyl; or R and R together with the carbon atom to which they are attached form a cycloalkyl; R is —C (O) NR R or benzooxazolyl; R, R and R are independently selected from hydrogen, al yl, halo, haloalkyl, alkoxy, haloalkoxy, and morpholinyl; the iodine of R and R is hydrogen or alkyl, and the other is alkyl, alkoxyalkyl, cycloalkyl, haloalkyl, phenylalkyl, naphthylalkyl or tetrahydropyranyl; or a pharmaceutically acceptable salt or ether thereof. 2. A compound according to claim 1, wherein R1 is halogeno-phenylcycloalkyl or halo-pyridinyl-cycloalkyl. 3. A compound according to claim 1, wherein R1 is chlorophenylcyclopropyl, chlorofluorophenylcyclopropyl, bromophenylcyclopropyl, bromofluorophenylcyclopropyl or chlorofluoropyridinylcyclopropyl. 4. A compound according to claim 1, wherein R and R are independently selected from hydrogen and alkyl. A compound according to claim 1, wherein R and R are independently selected from hydrogen, methyl, ethyl, propyl and butyl. A compound according to claim 1, wherein R, R and R are independently selected from halogen, haloalkyl and haloalkoxy. A compound according to claim 1, wherein R, R and R are independently selected from hydrogen, chloro, trifluoromethyl and trifluoroethoxy groups. A compound according to claim 1, wherein R4 is chlorine or trifluoromethyl. The compound according to claim 1, in which Rpr |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2736498-C1 |
| priorityDate | 2011-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 70.