http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2014123248-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-96 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-404 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-424 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4162 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 |
| filingDate | 2014-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2014123248-A |
| titleOfInvention | METHYL 1-Aryl-3-HYDROXY-3'-METHYL-2,4,5'-TRIOXO-6-Phenyl-2,4,5,6-TETRAHYDRO-5'H-SPIRO [INDOL-7,4'- ISOXAZOLE] -7a (1H) -CARBOXYLATES, METHYL 1-Aryl- (1'-Phenyl and 1'-Benzyl) -3-HYDROXY-3'-METHYL-2,4,5'-TRIOXO-6-Phenyl-1 ', 2,4,5,5', 6-HEXAGHYDROSPIRO [INDOL-7,4'-PYRAZOL] -7a (1H) -CARBOXYLATES AND METHYL 1'-Aryl-3'-HYDROXY-1,2 ', 3, 4'-TETRAOXO-6'-Phenyl-1,2 ', 3,4', 5 ', 6'-HEXAHYDROSPIRO [INDEN-2,7'-INDOL] -7a' (1'H) -CARBOXYLATES MANIFESTING AN ANALGETIC ACTIVITY AND METHOD FOR PRODUCING THEM |
| abstract | 1. Methyl 1-aryl-3-hydroxy-3′-methyl-2,4,5′-trioxo-6-phenyl-2,4,5,6-tetrahydro-5′H-spiro [indole-7.4 ′ -Isoxazole] -7a (1H) -carboxylates, methyl 1-aryl- (1′-phenyl and 1′-benzyl) -3-hydroxy-3′-methyl-2,4,5′-trioxo-6-phenyl -1 ′, 2,4,5,5 ′, 6-hexahydrospiro [indole-7,4′-pyrazole] -7a (1H) -carboxylates and methyl 1′-aryl-3′-hydroxy-1,2 ′, 3,4′-tetraoxo-6′-phenyl-1,2 ′, 3,4 ′, 5 ′, 6′-hexahydrospiro [inden-2,7′-indole] -7a ′ (1′H) -carboxylates of the formula where V, Ar = Ph (a), CHMe-4 (b), CHOMe-4 (c), where VI, Ar = Ph, R = Ph (a), CHPh (b); Ar = CHMe-4, R = Ph (c), CHPh (g); Ar = CHOMe-4, R = Ph (e), CHPh (e), where VII, Ar = Ph (a), CHMe-4 (b), CHOMe-4 (c). 2. Methyl 1-aryl-3-hydroxy-3′-methyl-2,4,5′-trioxo-6-phenyl-2,4,5,6-tetrahadro-5′H-spiro [indole-7,4′- isoxazole] -7a (1H) -carboxylates and methyl 1-aryl- (1′-benzyl and 1′-phenyl) -3-hydroxy-3′-methyl-2,4,5′-trioxo-6-phenyl-1 ′, 2,4,5,5 ′, 6-hexahydrospiro [indole-7,4′-pyrazole] -7a (1H) -carboxylates of the formula where V, Ar = Ph (a), CHMe-4 (b), CHOMe -4 (c) where VI, Ar = Ph, R = Ph (a), CHPh (b); Ar = CHMe-4, R = Ph (c), CHPh (g); Ar = CHOMe-4, R = Ph (d), CHPh (e) possessing analgesic activity. 3. The method of obtaining methyl 1-aryl-3-hydroxy-3′-methyl-2,4,5′-trioxo-6-phenyl-2,4,5,6-tetrahydro-5′H-spiro [indole-7.4 ′ -Isoxazole] -7a (1H) -carboxylates, methyl 1-aryl- (1′-benzyl and 1′-phenyl) -3-hydroxy-3′-methyl-2,4,5′-trioxo-6-phenyl -1 ′, 2,4,5,5 ′, 6-hexahydrospiro [indole-7,4′-pyrazole] -7a (1H) -carboxylates and methyl 1′-aryl-3′-hydroxy-1,2 ′, 3,4′-tetraoxo-6′-phenyl-1,2 ′, 3,4 ′, 5 ′, 6′-hexahydrospiro [inden-2,7′-indole] -7a ′ (1′H) -carboxylates, characterized in that methyl 1-aryl-3-cinnamoyl-4,5-dioxo-4,5-dihydro-1H-pyrrole-2-carboxylate is reacted with 3-methylisoxazole-5 (4H) -one (II), 1 -phenyl- (I IIa) and 1-benzyl-3-methyl-5-pyrazolone (IIIb) and 1H-indene-1,3 (2H) -dione (IV) in an inert aprotic solvent - toluene, at a temperature of 108-110 ° C for 2-2.5 hours for compounds (Va-c), 4-5 hours for compounds (VIa-e) and 8-9 hours for com |
| priorityDate | 2014-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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