http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2014122487-A
Outgoing Links
Predicate | Object |
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classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D237-08 |
filingDate | 2012-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 2015-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | RU-2014122487-A |
titleOfInvention | 1-Pyridazinyl-hydroxyimino-3-phenyl-propane as agonists conjugated to the G-protein bile acid receptor GPBAR1 |
abstract | 1. The compounds of formula where R is a heteroaryl selected from the group consisting of pyridazin-4-yl, 3-oxo-2,3-dihydropyridazin-4-yl and 6-oxo-1,6-dihydropyridazin-3-yl, wherein said heteroaryl is unsubstituted or substituted by one, two or three groups independently selected from the group consisting of C-alkyl, halogen, halogen-C-alkyl, hydroxy, hydroxy-C-alkyl, C-alkoxy and C-alkoxy-C -alkyl; R is selected from the group consisting of C1-6alkyl, C-cycloalkyl, C-alkenyl, halogen-C-alkyl, unsubstituted phenyl or phenyl substituted with one, two or three grams uppp independently selected from the group consisting of C-alkyl, halogen, halogen-C-alkyl, halogen-C-alkoxy and C-alkylsulfonyl, heteroaryl, which is unsubstituted or substituted by Calkyl or oxo, R and R are independently selected from the group consisting of hydrogen, halogen and C1-6alkyl; and R, R and R are independently selected from the group consisting of hydrogen, halogen, halogen-C-alkyl, cyano, cyano-C-alkyl, C-alkyl, C-alkenyl, C-alkynyl, C-alkoxy, C-alkoxy-C-alkyl , hydroxy, hydroxy-C-alkyl, hydroxy-C-alkenyl, hydroxy-C-alkynyl, hydroxy-C-alkoxy, carboxyl, carboxyl-C-alkyl, carboxyl-C-alkenyl, carboxyl-C-alkynyl, carboxyl-C -alkoxy, tetrazolyl, C-alkoxycarbonyl, C-alkylsulfonyl, C-alkylsulfonyloxy, C-alkylsulfonylamino, C-cycloalkylsulfonylamino, amino-sulfonyl, (C-alkyl) -aminosulfonyl, di- (C-alkyl) -aminosulfonyl, klsulfonyl, C-alkylamino, di- (C-alkyl) amino, C-alkoxy-C-alkylamino, C-alkoxy-C-alkyl-C-alkylamino, C-alkoxyhalo-C-alkylamino, hydroxy-C-alkyl- C-alkylamino, an amino acid residue attached through an amino group of an amino acid, C-cycloalkylamino, where C-cycloalkyl is not |
priorityDate | 2011-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 78.