http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2014122116-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-401 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-16 |
| filingDate | 2012-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2014122116-A |
| titleOfInvention | METHOD FOR PRODUCING 1-Acyl-4-Phenylsulfonylproline amide Derivatives and New Intermediate Compounds |
| abstract | 1. A method for producing proline derivatives of the formula I where R is selected from C-alkyl or where R is selected from C-alkyl, halogen-C-alkyl or phenyl optionally substituted with halogen; R is selected from halogen or halogen-C-alkyl; and R is selected from hydrogen, halogen, halogen-C-alkyl, C-alkoxy, halogen-C-alkoxy, or a 5- or 6-membered heterocycle containing one or two nitrogen atoms, the ring being optionally substituted with C-alkyl or halogen; comprising the following steps : a) the transformation of an alcohol of formula II wherein R is as described above into a sulfonate of formula III where R is as described above and R is C-alkyl, halogen-C-alkyl or phenyl optionally substituted with C-alkyl, nitro or bromine b) reaction of a sulfonate of formula III with a thio-compound where R and R are hydrogen or a protecting group to produce a thioether of formula V where R, R and R are as described above, and) oxidation of a thioether of formula V to produce a proline derivative of formula I, R, R, and R are as described above. 2. A method according to claim 1, wherein R 1 is a residue of the formula wherein R 1 is selected from C-alkyl, halogen-C-alkyl or phenyl optionally substituted with halogen. The method of claim 1, wherein R is selected from halogen or halogen-C-alkyl; and R is selected from a halogen-C-alkoxy or 5- or 6-membered heterocycle containing one or two nitrogen atoms, the ring being optionally substituted with C-alkyl or halogen. 4. The method of claim 1, wherein the remainder of the formula is where R and R are as described above. The method of claim 1, wherein the proline derivatives of formula I are chiral isomers of formula 6. The way you like |
| priorityDate | 2011-11-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 63.