http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2014120908-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J21-006 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J41-0083 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J21-006 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J71-001 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J7-0045 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J41-0094 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J41-00 |
| filingDate | 2012-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2014120908-A |
| titleOfInvention | METHOD FOR OBTAINING ACETETATE ULIPRISTAL AND ITS INTERMEDIATE PRODUCTS |
| abstract | 1. A method of producing ulipristal acetate, characterized in that it contains the following steps: where R is a hydroxyl protecting group selected from —CH (CH) —OR, —COR, or 2-tetrahydropyran; R1 and R2 are selected from a C-C1-6 alkyl or aryl radical, respectively; the dashed lines in formula V show the arrangement of double bonds at 5 (10), 9 (11) or 4 (5), 9 (10) .2. The method of claim 1, comprising the steps of: a) using 3,3- (ethylenedioxy) -19-norpregn-5 (10), 9 (11) -diene of 3.17-dione represented by formula II as starting material, and using alcohols as a reaction solvent in the presence of a cyan reagent to prepare the compound 3,3- (ethylenedioxy) -17β-cyano-7α-hydroxyl-19-norpregna-5 (10), 9 (11) -diene represented by formula III , in a weak acidic environment at a temperature of from -10 ° C to room temperature; b) preparing a Compound represented by Formula IV using the reaction of a Compound represented by Formula III, and a hydroxyl protecting group of the reagent in an acidic medium in a solvent; c) reacting a Compound represented by Formula IV with a methylation reagent and hydrolyzing a Compound represented by Formula IV in an acidic medium after a methylation reaction to obtain 5 (10), 9 (11) diene -3,20-dione, or 4 (5), 9 (10) -diene-3,20-dione represented by formula V, or mixtures thereof; d) the interaction of the compound represented by formula V with ethylene glycol by catalysis of p-toluenesulfonic acid and trimethyl orthoformate or triethyl orthoformate at room temperature perature in dichloromethane to yield compound 3,3- (ethylene-dioxy) -17α-hydroxy-19-norpregna-5 (10), 9 (11) -diene represented by formula VI; e) epoxidation of a compound represented by formula VI lane |
| priorityDate | 2011-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
| Predicate | Subject |
|---|---|
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID431529119 http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID90393054 |
Total number of triples: 19.