http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2014117678-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-715 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-554 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-605 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-26 |
| filingDate | 2012-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2014117678-A |
| titleOfInvention | Glucagon superfamily peptides with glucocorticoid receptor activity |
| abstract | 1. A compound containing a Q-L-Y structure; wherein Q is a glucagon superfamily peptide; Y is a GR ligand that activates a glucocorticoid receptor with an EC of about 1 μM or less and has a molecular weight of up to about 1000 daltons; and L is a linker or link. 2. The compound of claim 1, wherein Q exhibits at least 0.1% native GLP-1 activity against the GLP-1 receptor, at least 0.1% native glucagon activity against the glucagon receptor, at least , 0.1% activity of native GIP against the GIP receptor, or a combination thereof. 3. A compound according to claim 1, wherein Q has an EC for the GLP-1 receptor within a 10-fold ECY value for a glucocorticoid receptor, an EC for a glucagon receptor within a 10-fold ECY for a glucocorticoid receptor, an EC for a GIP receptor in within 10 times the ECY for the glucocorticoid receptor or a combination thereof. 4. A compound according to claim 1, wherein Y is a compound of the formula Formula where each of R, R, R, R, R, R and R independently is a moiety that permits agonistic or antagonistic activity when the compound of formula C is bound to a nuclear hormone receptor or glucocorticoid receptor or contribute to it; and each dotted line represents an optional double bond; and Y conjugated to L at position 3 or 17 Y.5. The compound of claim 4, wherein Y is cortisol or a derivative thereof. The compound of claim 5, wherein the cortisol or its derivative is selected from the group consisting of cortisol, cortisone acetate, beclomethasone, prednisone, prednisolone, methyl prednisone |
| priorityDate | 2011-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 138.