http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2014117635-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-05 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B59-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C251-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-497 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D241-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C269-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D309-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-04 |
| filingDate | 2012-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2014117635-A |
| titleOfInvention | METHODS FOR PRODUCING COMPOUNDS THAT CAN BE USED AS ATR KINASE INHIBITORS |
| abstract | 1. A process for preparing a compound of formula 4: from a compound of formula 3: under suitable oxime formation conditions; where R is C-alkyl; R is C-alkyl; or R and R, together with the oxygen atoms to which they are attached, form optionally substituted 5- or 6 a membered saturated heterocyclic ring having two oxygen atoms; R is hydrogen, C-alkyl or a 3-6 membered saturated or partially unsaturated heterocyclyl having 1-2 heteroatoms selected from the group consisting of oxygen, nitrogen and sulfur; moreover, heterocyclyl is optionally substituted with 1 copy of halogen or C-alkyl; J is H, halogen, C-alkyl or C-alkoxy; PG is a carbamate protecting group. 2. The method according to claim 1, used to obtain a compound of formula I: where R is; H is halogen, C-alkyl or C-alkoxy; Q is phenyl, pyridyl or N-alkylated pyridine; J is halogen; CN; phenyl; oxazolyl; or a C-aliphatic group, wherein a maximum of 2 methylene units are optionally replaced with O, NR ″, C (O), S, S (O) or S (O); said C-aliphatic group is optionally substituted with 1 to 3 fluoro or CN; q is 0, 1 or 2; and R 1 is hydrogen, C-alkyl or a 3-6 membered saturated or partially unsaturated heterocyclyl having 1-2 heteroatoms selected from the group consisting of oxygen, nitrogen and sulfur; wherein heterocyclyl is optionally substituted with 1 instance of halogen or C-alkyl. 3. The method according to claim 1 or 2, further comprising the step of protecting a compound of formula 2: under suitable conditions for introducing protection to form a compound of formula 3.4. The method of claim 3, further comprising the step of reacting the compound |
| priorityDate | 2011-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 24.