http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2014114381-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C309-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-496 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 |
| filingDate | 2012-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2014114381-A |
| titleOfInvention | Salts of Heterocyclyl Amide Substituted Imidazoles with Sulfonic Acid |
| abstract | 1. A salt of a compound of the formula wherein R is methyl, ethyl, butyl or cyclopropylmethyl, R is phenyl, where phenyl contains a substituent selected from the group consisting of trifluoromethoxy and difluoromethoxy, and R is hydrogen, methyl, chloro, methoxy or trifluoromethyl, with its organic sulfonate or hydrate. 2. Salt according to claim 1, characterized in that the organic sulfonic acid is methanesulfonic acid. The salt of claim 2, wherein the salt is a dimesylate. Salt according to claim 3, described by the following formula: 5. Crystalline dimesylate N- (1-methyl-2 - {[4- (5-methylpyridin-2-yl) piperazin-1-yl] carbonyl} -1H-imidazol-4-yl) -N ′ - [4-trifluoromethoxyphenyl] urea, the powder x-ray of which contains characteristic peaks at about 6.37, 11.77, 12.56, 17.17, 18.81, 20.34, 21.47, 23.04 and 35.46 degrees 2-theta .6. Crystalline dimesylate N- (1-methyl-2 - {[4- (5-methylpyridin-2-yl) piperazin-1-yl] carbonyl} -1H-imidazol-4-yl) -N ′ - [4-trifluoromethoxyphenyl] urea having a powder x-ray, in general form shown in FIG. 1.7. A method for producing compounds of formula (I) according to claim 1, which comprises reacting a compound of formula (I) or a salt of compounds of formula (I) with an acid that is not a salt with an organic sulfonic acid, with an organic sulfonic acid or with a source of sulfonate anions in solvent. 8. Salt according to one of paragraphs. 1-6, intended for use in a method for the treatment and / or prevention of diseases, preferably viral infections, preferably HMV infections or another member of the Herpesviridae group. 9. A pharmaceutical agent that contains a salt according to one of claims. 1-6 in combination at least |
| priorityDate | 2011-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 39.