http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2014109897-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-14 |
| filingDate | 2012-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2014109897-A |
| titleOfInvention | SERIN / THREONIN KINASE CANCER INHIBITORS |
| abstract | 1. A compound of formula I: wherein A is A-1 or A-2; Z is N or CR; R and R are (i) independently hydrogen, C 1-6 alkyl, C 1-6 haloalkyl, C 1 hydroxyalkyl or 1-4 alkoxyalkyl, or (ii ) R and R together represent (CH); R represents hydrogen, C1-6alkyl, Calkoxy or Cycloalkyl; R4 represents hydrogen, C-alkyl, Caloalkyl, C-hydroxyalkyl, Calkoxy-C1-6alkyl, Cycloalkyl, pyrrolidinyl, piperidinyl or RRN [R (R); hydrogen, C1-6alkyl or Cycloalkyl; R and R independently represent (i) hydrogen or C1-6alkyl or (ii) R and Rb naturally with the nitrogen to which they are attached is a ring of pyrrolidine and piperidine; R represents hydrogen, C1-6alkyl, Caloalkyl, Salkoxy, halogen, Cacyl or Caloalkanoyl; R represents independently in each case hydroxy, thiol, cyano, Calkyl, Calkoxy, Caloalkyl Haloalkoxy, halogen, Calkoxycarbonyl, carboxyl, Calkylthio, Chydroxyalkyl, nitro, amino, Calkylamino, Cialkylamino, amino-Calkyl, Calkylamino-Calkyl, Cialkylamino Calkyl, Calkylsulfonyl, arylsulfonylsulfonylamino-alkylsulfonyl, alkyl , arylsulfonylamido, carbamoyl, C1-6alkylcarbamoyl and Cdialkylcarbamoyl, arylcarbamoyl, C1-6alkylcarbonylamino, arylcarbonylamino; n represents zero, one, two or three; R4 represents hydrogen, C1-6alkyl, C1-6alkyl, C1-4 hydroxyalkenyl, C1-4 hydroxyalkenyl, R4-4; C 1-6 alkyl, C 1-6 haloalkyl, cyano, C 1 hydroxyalkyl or C 1-6 alkoxyalkyl; R is selected from the group consisting of: (i) C 1-6 alkyl, (2) C 1 haloalkyl, (3) optionally substituted Cycloalkyl, (4) Cycloalkyl-C 1-6 alkyl, (v) RO [C (R )], (vi) heterocyclyl and (vii) heterocyclyl-C1-6alkyl, (viii) cyanoal |
| priorityDate | 2011-08-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 70.