http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2014104377-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4025 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-421 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-444 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-55 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4025 |
| filingDate | 2012-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2014104377-A |
| titleOfInvention | METHOD FOR ATHEROSCLEROSIS TREATMENT IN SUBJECTS WITH A HIGH LEVEL OF TRIGLYCERIDES |
| abstract | 1. A method of treating, preventing or reducing the intensity of atherosclerosis or dyslipidemia, or a method of increasing HDL-C and / or lowering LDL-C, in a subject with high triglycerides, comprising administering to the subject a therapeutically effective amount of a compound of the following formula I: or a pharmaceutically acceptable salt thereof where: C is a central structure selected from: Y and Z are independently CH or N; rings A and B are independently phenyl or a 5- or 6-membered heteroaryl, where phenyl and heteroaryl are optionally substituted with 1-3 substituents independently selected from C1-6alkyl, C1-6 alkoxy, halogen, halo-C1-6alkyl, halogenoalkoxy, amino, C1-6alkylamino, di-C1-6alkylamino, Cycloalkyl and Cycloalkoxy; D is Cycloalkyl, phenyl, 5- or 6-membered heteroaryl, where phenyl and optionally heteroaryl substituted by 1 to 3 substituents independently selected from 1 to 3 substituents independently selected from C 1-6 alkyl, C 1-6 alkoxy, CN, NO, C 1-6 cycloalkyl-C 1 -alkyl, halogen, halo-1-C 1 -alkyl, halo-1-C 2 alkoxy, amino, 1-6 C-alkylamino, 2-C 1 -alkylamino, 1-6 cycloalkyl and 1-6 cycloalkoxy ; L is a linker selected from Calk sludge (straight or branched), or a linker selected from: with the proviso that the central structure C and L do not form an NN bond or NO bond; X is absent or is CR, where R forms the following ring with R: R is C (O) O-alkyl, C (O) -alkyl or 5- or 6-membered heteroaryl, optionally substituted with 1-3 substituents independently selected from C1-6alkyl, hydroxy-C1-6alkyl, Calkoxy, which is optionally substituted with Calkoxy, hydroxy, halogen or -S (O) C1-6alkyl; amino, C1-6alkylamino, di-C1-6alkylamino, amino-C1-6alkyl, C1-6alkylamino-C1-6alkyl, di-C1-6alkylamino-1-6alkyl, (hydroxySalk |
| priorityDate | 2011-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 113.