http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2014103806-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F5-025 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F5-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 2012-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2014103806-A |
| titleOfInvention | METHODS AND INTERMEDIATE COMPOUNDS FOR OBTAINING AZINDOLES |
| abstract | 1. A process for preparing a compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: R is —H, —Cl or —F; R is —H or —F; R is a —Caliphatic group, optionally with 1-5 substitutions with R; R 1 is -C 1-6 alkyl, optionally with 1 to 3 substitutions with R; or R and R taken together form a 3-7 membered carbocyclic or heterocyclic saturated ring, optionally with 1-5 substitutions for R; each R is independently selected from halogen, —OCH, —OH, —NO, —NH, —SH, —SCH , —NHCH, —CN or an unsubstituted —Caliphatic group, or two R groups, together with the carbon to which they are attached form a cyclopropyl ring; R is —H or an unsubstituted —Calkyl; and R is —CHCR or - (CH) CR, where each R independently is —H or —F; comprising the step of: i) reacting a compound of formula 1 with a hydrochloride salt of a compound of formula 2 in the presence of water, an organic solvent, a base and a transition metal catalyst to obtain compounds of formula I.2. The method of claim 1, wherein the organic solvent of step i) is an aprotic solvent. The method of claim 2, wherein the aprotic solvent is acetonitrile, toluene and N, N-dimethylformamide, N, N-dimethylacetamide, acetone, methyl tert-butyl ether, or any combination thereof. The method according to any one of paragraphs. 1-3, where the organic solvent of step i) is a protic solvent. 5. The method of claim 4, wherein the protic solvent is an alcohol selected from methanol, propanol, isopropanol, butanol, tert-butanol, or any combination thereof. The method according to any one of paragraphs. 1-5, where the base of step i) is an inorganic base. 7. The method according to p. |
| priorityDate | 2011-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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