| abstract |
1. Non-woven material containing: fibers of fibrous raw material containing bioresorbable and / or biocompatible polymers, and these fibers include at least one biologically active substance, which is distributed in these fibers, where this biologically active substance is GDF-5-related protein , which is a protein containing a cystine-node-domain with an amino acid identity of at least 60% relative to 102 aa-cystine-node-domain of human GDF-5, corresponding to amino acids 400-501 of SEQ ID NO: 2.2. The nonwoven material according to claim 1, wherein the biologically active protein is further distributed on these fibers. The nonwoven fabric of claim 2, wherein the GDF-5-related protein is a protein containing a cystine host domain with an amino acid identity of at least 70%, 80%, 90%, or 95% relative to 102 aa-cystine host domain of the GDF -5 people. 4. The nonwoven fabric according to claim 1, wherein the fibrous raw material is selected from the group consisting of natural polymers, synthetic polymers and polymers made from conservative raw materials, each of which may be modified or unmodified, and combinations thereof. The non-woven material according to claim 4, where the natural polymers are selected from the group consisting of polypeptides such as collagen, gelatin, fibrin, casein or polysaccharides such as dextran, cellulose, starch, chitin, chitosan, alginate and hyaluronic acid, or polynucleotides, as well as synthetic polymers such as polylactide (PLA), polyglycolide (PGA), polycaprolactone (PCL), polyvinylpyrrolidone (PVP), polyethylene oxide (PEO), polyethylene glycol (PEG), polyhydroxy ethers, or combinations thereof. 6. Non-woven material according to claim 1, where this substance |