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filingDate 2012-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2015-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber RU-2014101690-A
titleOfInvention COMPOSITIONS FOR THE DELIVERY OF MEDICINES
abstract 1. A thermogenic formulation for use in transdermal drug administration, wherein said drug is present in said formulation or in a second formulation, one or more penetration enhancers present in one or both of the formulations, and wherein at least one penetration enhancer is C -compound containing at least one -Alk-O- group in which Alk is C-alkylene and if only one -Alk-O- group is present, then Alk can also be a C-alkyl group. The composition of claim 1, wherein said thermogenic composition comprises supercooled saline. The composition of claim 1, wherein said thermogenic composition is prepared in situ or just prior to use by combining a solvent, preferably water, with at least one anhydrous salt capable of generating heat upon hydration, the salts are preferably selected from anhydrous forms of calcium chloride (CaCl) salts and magnesium sulfate (MgSO). 4. The composition of claim 1, wherein said thermogenic composition comprises monomers capable of generating heat upon polymerization upon addition of a suitable catalyst, preferably bisphenol-A (BPA) and epichlorohydrin (ECH) monomers. The composition of claim 1, wherein the thermogenic composition is capable of reaching a temperature of at least 40 ° C and preferably not more than 50 ° C. The composition of claim 5, wherein the thermogenic composition is adapted to achieve a temperature of 42 ° C to 45 ° C inclusive. A composition according to claim 5 or 6, wherein the thermogenic composition is adapted to maintain a temperature above 32 ° C for at least 5 minutes, preferably at least 10 minutes, and preferably for a
priorityDate 2011-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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