http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2013157328-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-726 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57434 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-575 |
| filingDate | 2013-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2013157328-A |
| titleOfInvention | PEPTIDE AND NEPEPTIDE LIGANDS FOR IMMUNODETECTION OF THE UROTENZINE II RECEPTOR |
| abstract | 1. Cyclic peptides of general formula (I) containing biotin or other fluorophore groups at the N-terminal position: Bio-X-UHKno [ZABCD-Cys] -Y (I) where: X is selected from the group consisting of H, Η- Asp, H-Phe, HD-Phe, Gly, Gly-Gly, H-Glu-Thr-Pro-Asp, and other spacers; Y is selected from the group consisting of OH, NH, Val-OH, Val-NH, Il -OH and Ile-NH; A and D, identical or different from each other, are selected from the group consisting of Phe, D-Phe, Tyr, D-Tyr, cyclohexyl alanine and cyclopentyl alanine; B is selected from the group consisting of from D-Trp, D- (α-Me) Trp, D-Trp (Me), D-Trp (CHO), D-Nal (l) nD-Nal (2); C is selected from the group consisting of Lys, Asp, Glu, Orn, Cit, Dap, Dab and (p-amino) Phe; Ζ is Xia Pen or Cys; Bio is a marker; or a pharmaceutically acceptable soli.2. The cyclic peptides of claim 1, wherein said marker is selected from fluorophore agents and radiolabels with a radioactive isotope. The cyclic peptides of claim 2, wherein said fluorophore markers are selected from biotin, fluorescein isothiocyanate, rhodamine. The cyclic peptides of claim 2, wherein said radiomarkers are selected from Tc, I, I, F, Ga, Sc, Y. 5. Cyclic peptides of the formula (I) according to claims 1-4, in which C is selected from the group consisting of Lys, Orn, and (p-amino) Phe. 6. The cyclic peptides of formula (I) according to claim 1, wherein B is D-Trp and C is Orn. 7. The cyclic peptides of formula (I) according to claim 1, wherein X is H-Asp, Y is Val-OH, B is D-Trp, and C is Orn. 8. The cyclic peptides of formula (I) according to claim 1, selected from the following compounds: Bio-Asp-cyclo [Pen-Phe-Trp-Lys-Tyr-Cys] -Val-OH (SEQ ID NO. 1) Bio-Asp-cyclo [Cys-Phe-Trp-Lys-Tyr-Cys] -Val-OH (SEQ ID NO. 2) Bio-Asp-cyclo [Pen-Phe-DTrp-Orn-Tyr-Cys] -Val-OH (SEQ ID NO 3) Bio-Asp-cyclo [Pen-Phe-Lys-Tyr-Cys] -Val-NH (SEQ ID NO. 4) Bio-Asp-cyclo [Pen-Phe-DTrp-Orn-Tyr-Cys] -Val -NH (SEQ ID NO. 5) Bio-Glu-Thr-Pro-Asp-cyclo [Pen-Phe-Trp-Lys-Tyr-Cys] -Val-OH (SEQ ID NO. 6) Bio-Glu-Tyr- Rro-Asr-cyclo [Ren-Phe-DTrp-Orn-Tur-Cus] -Va1-OH (SEQ ID NO. 7) Bio-Asr-cyclo [Ren-DPhe-DTrp-Orn-Tur-Cus] -Va1- OH (SEQ ID NO. 8) Bio-A |
| priorityDate | 2007-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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