http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2013153533-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00 |
| filingDate | 2012-05-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2013153533-A |
| titleOfInvention | METHODS FOR PRODUCING HEPATITIS C VIRUS INHIBITORS |
| abstract | 1. A process for the preparation of a compound of formula I, wherein A and E independently represent a direct bond; R is —NH (C-C1-6 alkyl); R is C-C1-6 alkyl; R is independently selected from the group consisting of C-C1-6 alkyl, C-C1-6 alkyl -Cycloalkyl) and substituted C-C1-6alkyl (C-Cycloalkyl); or R and R are each independently selected from the group consisting of H, C-C1-6alkyl, C-Cycloalkyl, C-C1-6alkyl (C-Cycloalkyl) and substituted C-C1-6alkyl (C-Cycloalkyl), or R and R can be taken together to form C-Cycloalkyl; R and R are independently are methyl, wherein the process comprises: reacting a compound of formula II: wherein A, E, R, R, R, R, R, R and R are as defined above, with an oxidizing agent selected from the group consisting of KMnO, NaMnO; KFeO, VO, RuO, NaNO, CrO, KCrO, KCrO / HPVMOO, peroxides and PhI (OAc), in the presence of at least one catalyst to give a compound of formula I.2. The method of claim 1, wherein R is selected from —NHCH, —NHCHCH, —NHCHCHCH, —NHCH (CH), —NHCHCHCHCH, —NHCH (CH) CHCH, NHCHCH (CH), —NHC (CH), —NHCHCHCHCHCHCH and NHCHCHCHCHCHCH.3 . The method according to claim 1, wherein R is selected from —CH, —CHCH, CHCHCH, CH (CH), CHCHCHCH, —CH (CH) CHCH, —CHCH (CH), —C (CH), CHCHCHCH — CHCHCHCHCH. . The method according to claim 1, wherein R is selected from the group consisting of —C — C1-6alkyl or - (CH) (cyclo (C — C) alkyl). The method according to claim 1, wherein R and R are independently selected from the group consisting of H, C-C1-6alkyl, C-Cycloalkyl, C-C1-6alkyl (C-Cycloalkyl) and substituted C-C1-6alkyl (C-Cycloalkyl). The method of claim 1, wherein R and R taken together form C-Cycloalkyl. The method of claim 1, wherein R and R are independently selected from the group consisting of H and C-C1-6alkyl. A method according to claim 1, wherein R is —NHC (CH), R is —C (CH), R is R is H, R is H, R is methyl, and R is methyl. The method according to claim 1, where, at least |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2794755-C1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2794754-C1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2794750-C1 |
| priorityDate | 2011-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 38.