| abstract |
1. A copolymer / enhancer composition for topical delivery of therapeutic agents through the skin and mucosal surfaces, comprising a heat-sensitive polymer, mucoadhesive or skin-adhesive polymer, penetration enhancer and therapeutic agent. The copolymer / enhancer composition according to claim 1, wherein the heat-sensitive polymer comprises poloxamer or poloxamine. The copolymer / enhancer composition according to claim 1, wherein the poloxamer is selected from the group consisting of poloxamer 188, 407, 101, 105, 108, 122, 123, 124, 181, 182, 183, 184, 185, 212, 215, 217 , 231, 234, 235, 237, 238, 282, 284, 288, 331, 333, 334, 335, 338, 401, 402 and 403, and poloxamine is selected from the group consisting of poloxamine 304, 504, 701, 702, 704, 707, 901, 904, 908, 1101, 1102, 1104, 1301, 1302, 1304, 1307, 1501, 1502, 1504, and 1508.4. The copolymer / amplifier composition according to claim 3, wherein the heat-sensitive polymer is poloxamer 188.5. The copolymer / enhancer composition according to claim 1, wherein the mucoadhesive or skin-adhesive agent is selected from the group consisting of propylene glycol, dipropylene glycol, polyethylene glycol, glycerol, butylene glycol, glycol derivatives with glycerol esters and non-ionizable glycol ether derivatives. The copolymer / enhancer composition according to claim 5, wherein the mucoadhesive or skin-adhesive agent is propylene glycol. The copolymer / enhancer composition of claim 1, wherein the penetration enhancer is selected from the group consisting of laurocapram, diethylene glycol, monoethyl ether, n-decylmethyl sulfoxide, dimethyl sulfoxide, dimethylacetamide-dimethylformamide, sucrose mono-oleate, urea, 2-pyrrolidone -pyrrolidone, ethanolamine, diethanolamine and triethanolamine, citric acid, succinic acid, N-meth |