| abstract |
1. A compound of the formula: or a pharmaceutically acceptable salt thereof, wherein: A is an aryl or 4-7 membered heterocycle; X is N or CH; each Y and Y is independently S, N or CH, provided that at least one of Y and Y is N or CH; each R is independently R, - (R) SOR, - (R) SON (R), - (R) NRSOR, - (R) C (O) N (R) or - (R) NRC (O) R, or optionally substituted C-hydrocarbyl or 2-12 membered heterocarbyl, with optionally one or more R being substituted; each R is independently amino, alkoxyl, carboxyl, cyano, ha fire or hydroxyl; each R is independently Hydrocarbyl, optionally substituted with one or more of amino, alkoxyl, carboxyl, cyano, halogen or hydroxyl; each R is independently hydrogen or optionally substituted with Hydrocarbyl or a 2-12 membered heterocarbyl, with one optional more of amino, alkoxyl, carboxyl, cyano, halogen or hydroxyl; R and R taken together form a 5-7 membered heterocycle optionally substituted with one or more R, or: R is hydrogen or C1-6 alkyl ; and R is hydrogen or an optionally substituted C-hydrocarbyl or a 2-12 membered heterocarbyl, with one or more R being optionally substituted; each R is independently amino, alkoxyl, carboxyl, cyano, halogen or hydroxyl; k is 0 or 1; m is 0 or 1; m is 0 or 1; m is 0 -3; n represents 0 or 1; and p is 0-2; provided that R is not hydrogen when X is CH, Y is CH, Y is CH and R is hydrogen. 2. A compound according to claim 1, wherein R is not hydrogen. The compound according to claim 1, which has |