| abstract |
1. A compound of formula I: wherein: R is selected from —OR and —NRR; R is selected from —CHOH, —CHOP (O) (OH) and —CHOC (O) CH (R) NH; or R together with R forms —CHO — CRR— or together with R forms —CHO — C (O) -; R is selected from H and —CH, or together with R forms —CH — O — CH—; Z is selected from —CH— and —N -; X is —C heteroaryl; R is absent or selected from H; halogen; -Calkylene-OH; -NH; C1-6alkyl; -CF; -Cycloalkyl; -Alkylene-O-alkyl; -C (O) R; -Calkylene-COOR; -C (O) NRR; -NHC (O) R; = O; -NO; -C (CH) = N (OH); phenyl optionally substituted with one or two groups independently selected from halogen, —OH, —CF, —OCH, —NHC (O) CH and phenyl; naphthalenyl; pyridinyl; pyrazinyl; pyrazolyl, optionally substituted with methyl; thiophenyl, optionally substituted with methyl or halogen; furanyl; and -CH-morpholinyl; and R, if present, is attached to a carbon atom; R is absent or selected from H; -OH; C1-6alkyl; -Calkylene-COOR; -CHOC (O) CH (R) NH; -OCHOC (O) CH (R) NH; -OCHOC (O) CH; -CHOP (O) (OH); -CHCH (OH) CHOH; -CH [CH (CH)] -NHC (O) O-C1-6 alkyl; pyridinyl; and phenyl or benzyl, optionally substituted with one or more groups selected from halogen, —COOR5, —OCH, —OCF and —SCF; and R, if present, is attached to a carbon or nitrogen atom; or R and R together form -phenylene-O- (CH) - or -phenylene-O-CH-CHOH-CH-; a = 0 or 1; R is selected from halogen, —CH, —CF and —CN; b = 0 or an integer from 1 to 3; each R is independently selected from halogen, —OH, —CH, —OCH and —CF; R is selected from H, —Calkyl, —Calkylene-Caryl, —Calkylene-Ceteroaryl, —Cycloalkyl, - [(CH) O] CH, —Calkylene-OC (O) R, -Calkylene-NRR, -Calkylene-C (O) R, -Calkylene morpholinyl, -Calkylene-SO-C 1-6 alkyl; R selected from -C 1-6 alkyl, -O-C 1-6 alkyl, -Cycloalkyl, -O-C 1 cycloalkyl, phenyl, - O-phenyl, -NRR, -CH [CH (CH)] -NH, -CH [CH (CH)] -NHC (O) O-C1-6 alkyl and -CH (NH) CHCOOCH; and R and R are independently selected from H, -Calkyl and benzyl, or R and R together form - (CH) -, -C (O) - (CH) - or - (CH) O (CH) -; R is selected from —O — C1-6alkyl, —O-benzyl and —NRR; and R stands for -Cal� |