| abstract |
1. The quinoline substituted by the phosphorus group represented by the following formula (I): wherein in the formula (I) Z is, each of V and V is independently selected from hydrogen, halogen, —OCF, —CF, —NO, —CN, —OH , -NH, -NMe, C1-6alkyl, Cycloalkyl, Cetherocycloalkyl, C-alkoxy, Cycloalkoxy or Ceterocycloalkoxy; one of R and R ′ is a phosphorus substituent Q, the other is selected from hydrogen, methoxy, methoxyethoxyl or a phosphorus-containing substituent Q; represents, A is absent or represents O, NH, S (= O) or C1-6alkyl, and A is optionally substituted with G; L is absent or represents C1-6alkyl, Cycloalkyl, Caryl, Ceteroaryl or Ceterocycloalkyl, and L is optionally substituted with G; J is absent or is O, NH, S ( = O), C1-6alkyl, Cycloalkyl, Caryl, Heteroaryl or Ceterocycloalkyl, and J is optionally substituted with G; X is absent or represents -C (= O) -, -S (O) -, Ci-6alkyl, Cycloalkyl, Caryl, Ceteroaryl or Ceterocycloalkyl, and X is optionally substituted with G; Y is absent or represents C1-6alkyl, Cycloalkyl, Caryl, Ceteroaryl or Ceterocycloalkyl, and Y is optionally substituted with G; each of R and Rh independently selected from —OH, C1-6alkyl, Cycloalkyl, Caryl, Ceteroaryl, Ceterocycloalkyl, Calkoxy, Cicycloalkoxy, Caryloxy, Ceteroaryloxy or Ceterocycloalkoxy, and each of R and R is optionally substituted with G; R and R, together with the phosphorus atom to which they are attached, can form a C heterocycloalkyl ring, which may additionally contain heteroatom (s) selected from O, N or S (= O); where each of G, G, G, G, G and G are independently selected from H, —CN, —CF, —COH, halogen, C1-6alkyl, Cycloalkyl, C1-6alkenyl, C1-6alkynyl, Caryl, Ceteroaryl, Ceterocycloalkyl, RO-, RRN-, RS (= O) -, RRNS (= O) |