| abstract |
1. A compound having formula I, its enantiomers, diastereoisomers, hydrates, solvates, crystalline forms and individual isomers, tautomers or pharmaceutically acceptable salts thereof, wherein R is H or substituted or unsubstituted C1-6 alkyl; R is H or substituted or unsubstituted C1-6 alkyl; R is N or CR; R is N or CR; R is substituted or unsubstituted C1-6alkyl, substituted or unsubstituted heterocycle, substituted or unsubstituted Cycloalkyl, substituted or unsubstituted Cycloalkenyl or substituted or unsubstituted Sari ohm; R is 2-benzofuran, 2-thienyl, 5-chloro-2-thienyl, 4,5-dichloro-2-thienyl, 4-chloro-3-methylphenyl or 4-chloro-3-trifluoromethylphenyl; R is N or CR; R is N or CR; R is H substituted or unsubstituted with C1-6alkyl, halogen, -OCalkyl, CN, Calkenyl, C1-6alkynyl, C (O) R, NRR or hydroxyl; R is H, substituted or unsubstituted with C1-6alkyl, halogen, -OCalkyl, CN, Calkenyl, Calkynyl, C (O) R, NRR or hydroxyl; R is H, substituted or unsubstituted Calkyl, halogen, -OCalkyl, CN, Calkenyl, Calkynyl, C (O) R, NRR or hydroxyl; R is H, substituted or not substituted by C1-6alkyl, halo, -Oalkyl, CN, C2-6alkenyl, C1-6alkynyl, C (O) R, NRR or hydroxyl; R is H or substituted or unsubstituted C1-6 alkyl; R is H or substituted or unsubstituted C1-6 alkyl; R is H or substituted or unsubstituted C1-6 alkyl; R is H or substituted or unsubstituted C1-6 alkyl; R is H or substituted or unsubstituted C1-6 alkyl; R is H or substituted or unsubstituted C1-6 alkyl; R is H or substituted or unsubstituted C1-6 alkyl; R is H or substituted or unsubstituted C1-6 alkyl; R is H or substituted or unsubstituted |