http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2013126497-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B59-001 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C303-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C269-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B59-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C309-73 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C309-65 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-18 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C269-06 |
| filingDate | 2011-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-01-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2013126497-A |
| titleOfInvention | SIMPLIFICATION OF THE METHOD FOR OBTAINING THE PREDEDENT COMPOUND |
| abstract | 1. A method of obtaining a compound of formula (II):, where x is an integer from 0 to 4; comprising: (a) debenzylation of a compound of formula Ia: where R is a straight or branched chain alkyl group; R is an amino protecting group; and v is an integer from 0 to 4; to obtain a compound of formula Ib: where R, R and w are as defined for R, R and v in formula Ia, respectively; (b) the conversion of a compound of formula Ib obtained directly in step ( a) to a compound of formula I: wherein R, R and n are as defined for R, R and v in formula Ia, respectively; and X represents a leaving group selected from a halogen or a group —O — SO — R, where R is halogen, straight chain or branched C1-6 alkyl, straight or branched chain haloalkyl and Caryl; wherein said conversion is carried out by reacting said compound of the formula Ib with a suitable form X as defined for formula I; c) reacting a compound of formula I obtained in step (b) with a suitable source of F-fluoride to give a compound of formula IIa: where R, R and y are as defined for R , R and v Formula Ia, respectively; and (d) deprotecting the compound of formula IIa obtained in step (c) to remove R and R.2. The method according to claim 1, where X is a group-O-SO-R. 3. The method according to claim 2, wherein R is selected from the group consisting of toluenesulfonic acid, nitrobenzenesulfonic acid, benzenesulfonic acid, trifluoromethanesulfonic acid, fluorosulfonic acid, perfluoroalkylsulfonic acid, trimethylstannyl and triethylstannyl. 4. The method according to claim 3, wherein R 1 is trifluoromethanesulfonic acid. The method according to p. |
| priorityDate | 2010-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 41.