http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2013124423-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-526 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-524 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-468 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-46 |
| filingDate | 2011-11-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2014-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2013124423-A |
| titleOfInvention | DESIGN OF A SUSTAINABLE HETERODIMER ANTIBODY WITH MUTATIONS IN FC DOMAIN |
| abstract | 1. An isolated heteromultimer containing a heterodimeric Fc region that includes a variant CH3 domain containing amino acid mutations stimulating the formation of a heterodimeric Fc region with increased stability compared to a CH2 domain that does not contain amino acid mutations and where the variant CH3 domain has a melting point (Tm ) about 70 ° C or higher. 2. The isolated heteromultimer according to claim 1, wherein the heterodimeric Fc region further comprises a variant CH2 domain containing asymmetric amino acid modifications to stimulate selective binding of the Fc gamma receptor. The isolated heteromultimer according to claim 2, wherein the variant CH2 domain selectively binds the Fc gamma IIIa receptor compared to the wild-type CH2 domain. An isolated heteromultimer according to any one of claims 1 to 3, in which the heterodimeric Fc region does not contain an additional disulfide bond in the CH3 domain compared to the wild-type Fc region. An isolated heteromultimer according to any one of claims 1 to 3, in which the heterodimeric Fc region contains an additional disulfide bond in the variant CH3 domain compared to the wild-type Fc region, provided that a melting point (Tm) of about 70 ° C or higher is observed in the absence additional disulfide bond. 6. An isolated heteromultimer according to any one of claims 1 to 3, in which the heterodimeric Fc region contains an additional disulfide bond in the variant CH3 domain compared to the wild-type Fc region, and the variant CH3 has a melting point (Tm) of about 77.5 ° C or higher. The isolated heteromultimer according to any one of claims 1 to 3, in which the heterodimeric Fc region has a purity higher than about 90% .8. Highlighted hetero�� |
| priorityDate | 2010-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 25.