http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2013119438-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2400-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y302-01017 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-143 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0051 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-025 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-3955 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0024 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1709 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00 |
| filingDate | 2011-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2014-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2013119438-A |
| titleOfInvention | SILICON-BIOGRADABLE DEVICES FOR THE DELIVERY OF THERAPEUTIC AGENTS |
| abstract | 1. A device containing a biodegradable porous silicon carrier material impregnated with at least one high molecular weight therapeutic agent. The device according to claim 1, characterized in that the carrier material is absorbable. The device according to claim 1, characterized in that the therapeutic agent is selected from proteins, peptides, antibodies, carbohydrates, polymers and polynucleotides. The device according to claim 3, characterized in that the therapeutic agent is an antibody. The device according to claim 1, characterized in that the silicon carrier material is amorphous. The device according to claim 1, characterized in that the carrier material has a porosity of at least about 40%. The device according to claim 1, characterized in that the average pore size is in the range of 2-50 nm. The device according to claim 1, characterized in that the surface area of the carrier material is between 20 and 1000 m / g. The device according to claim 1, characterized in that the filling level of the carrier material is less than 5% by weight, based on the total weight of the carrier material and the therapeutic agent. A method of manufacturing a device according to any one of claims 1 to 9, comprising contacting the porous silicon carrier material with a therapeutic agent. The method according to claim 10, characterized in that the average pore size of the carrier material is chosen to ensure the entry of the therapeutic agent and the controlled release of the therapeutic agent into the biological medium for at least about three days. The method according to claim 11, characterized in that the average pore size is from about 15 to about 40 nm and the therapeutic agent has a molecular weight of from about 100,000 to about 200,000 amu. Cn |
| priorityDate | 2010-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
| Predicate | Subject |
|---|---|
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID5461123 http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID419559541 |
Total number of triples: 25.